D125407

Sigma-Aldrich

DIC

99%

Synonym(s):
N,N′-Diisopropylcarbodiimide
Linear Formula:
(CH3)2CHN=C=NCH(CH3)2
CAS Number:
Molecular Weight:
126.20
Beilstein/REAXYS Number:
878281
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

99%

reaction suitability

reaction type: Coupling Reactions

application(s)

peptide synthesis: suitable

refractive index

n20/D 1.433 (lit.)

bp

145-148 °C (lit.)

density

0.815 g/mL at 20 °C (lit.)

SMILES string

CC(C)N=C=NC(C)C

InChI

1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3

InChI key

BDNKZNFMNDZQMI-UHFFFAOYSA-N

Gene Information

human ... EPHX2(2053)
mouse ... Ephx2(13850)

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General description

DIC is an abbreviated form of N,N′-diisopropylcarbodiimide. It plays a role in the cyclization of N-(β-hydroxy)amides to form 2-oxazolines.

Application

DIC (N,N′-Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N-allylglycine to form N-allylpeptide.
Coupling reagent for peptide syntheses.
Alternative to dicyclohexylcarbodiimide in peptide synthesis.

Packaging

5, 25, 100, 500 g in glass bottle
1 kg in glass bottle
10 kg in poly drum

Signal Word

Danger

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 2929 3(6.1) / PGII

WGK Germany

WGK 3

Flash Point(F)

91.4 °F

Flash Point(C)

33 °C

Tetrahedron Letters, 35, 5981-5981 (1994)
Collection of Czechoslovak Chemical Communications, 59, 691-691 (1994)
Synthesis of 2-oxazolines mediated by N,N'-diisopropylcarbodiimide.
Crosignani S, et al.
Tetrahedron Letters, 45(52), 9611-9615 (2004)
Cody L Gilleland et al.
Genetics, 201(1), 39-46 (2015-07-15)
A major goal in the study of human diseases is to assign functions to genes or genetic variants. The model organism Caenorhabditis elegans provides a powerful tool because homologs of many human genes are identifiable, and large collections of genetic...
Anupam Patgiri et al.
Nature protocols, 5(11), 1857-1865 (2010-10-30)
Stabilized α-helices and nonpeptidic helix mimetics have emerged as powerful molecular scaffolds for the discovery of protein-protein interaction inhibitors. Protein-protein interactions often involve large contact areas, which are often difficult for small molecules to target with high specificity. The hypothesis...
Articles
Amide bonds are ubiquitous in both nature and industrial applications. They are vital to the structure and function of biological macromolecules and polymers. The importance of this functionality has resulted in numerous approaches to its formation, ranging from stoichiometric activation of carboxylic acids to more recent advances in catalytic amide bond formation.
Read More

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