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F5062

Sigma-Aldrich

Fmoc-Lys(Me)3-OH Chloride

≥97%

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Synonym(s):
Fmoc-Lys(Me3Cl)-OH, N-alpha-Fmoc-N-alpha-trimethyl-N-L-lysine · chloride
Empirical Formula (Hill Notation):
C24H31ClN2O4
CAS Number:
Molecular Weight:
446.97
NACRES:
NA.26

Quality Level

Assay

≥97%

form

liquid

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

application(s)

peptide synthesis

functional group

Fmoc

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C24H30N2O4.ClH/c1-26(2,3)15-9-8-14-22(23(27)28)25-24(29)30-16-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21;/h4-7,10-13,21-22H,8-9,14-16H2,1-3H3,(H-,25,27,28,29);1H/t22-;/m0./s1

InChI key

XUJRNPVABVHOAJ-FTBISJDPSA-N

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Fmoc-Lys(Me₃Cl)-OH Novabiochem®

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Fmoc-Lys(Me₃Cl)-OH

Fmoc-Lys(ivDde)-OH Novabiochem®

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8.52082

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Fmoc-Lys(Dnp)-OH Novabiochem®

Sigma-Aldrich

8.52099

Fmoc-Lys(Dnp)-OH

form

liquid

form

powder

form

powder

form

powder

functional group

Fmoc

functional group

amine

functional group

amine

functional group

Fmoc

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

15-25°C

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

application(s)

peptide synthesis

application(s)

peptide synthesis

application(s)

peptide synthesis

application(s)

peptide synthesis

General description

Fmoc protected N-trimethyl lysine

Application

Fmoc-Lys(Me)3-OH chloride is one of the common N-terminal protected reagents used in the peptide synthesis. Some of the reported examples are:
  • Synthesis of peptide linkers for monoclonal antibody-auristatin F conjugates.
  • Preparation of multifunctional reagents with enhanced ionization properties for the analysis of protein modification in human cells and dynamic profiling of protein lipidation.
  • Sequential peptide ligation to synthesize histone H3 containing a trimethyl lysine residue, with modified tail region.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Novel peptide linkers for highly potent antibody? auristatin conjugate.
Doronina S O, et al.
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Sequential Peptide Ligation by Combining the Cys?Pro Ester (CPE) and Thioester Methods and Its Application to the Synthesis of Histone H3 Containing a Trimethyl Lysine Residue.
Kawakami T, et al.
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