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H146

4-Hydroxymephenytoin

≥98% (HPLC)

Synonym(s):

(±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylhydantoin, (±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylimididazolidine-2,4-dione

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5 MG

$355.00

$355.00

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About This Item

Empirical Formula (Hill Notation):
C12H14N2O3
CAS Number:
61837-65-8
Molecular Weight:
234.25
NACRES:
NA.22
PubChem Substance ID:
57654234
UNSPSC Code:
12352100
MDL number:
MFCD00142316

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Product Name

4-Hydroxymephenytoin, ≥98% (HPLC)

InChI

1S/C12H14N2O3/c1-3-12(8-4-6-9(15)7-5-8)10(16)14(2)11(17)13-12/h4-7,15H,3H2,1-2H3,(H,13,17)

SMILES string

CCC1(NC(=O)N(C)C1=O)c2ccc(O)cc2

InChI key

OQPLORUDZLXXPD-UHFFFAOYSA-N

assay

≥98% (HPLC)

solubility

DMSO: >5 mg/mL

Quality Level

100

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Show Differences

1 of 4

This Item
UC126UC175SML1381
4-Hydroxymephenytoin ≥98% (HPLC)

Sigma-Aldrich

H146

4-Hydroxymephenytoin

4-Hydroxymephenytoin

Sigma-Aldrich

UC126

4-Hydroxymephenytoin

(S)-(+)-Mephenytoin solid, ≥98% (HPLC)

Sigma-Aldrich

UC175

(S)-(+)-Mephenytoin

PIK-294 ≥98% (HPLC)

Sigma-Aldrich

SML1381

PIK-294

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

solubility

DMSO: >5 mg/mL

solubility

-

solubility

DMSO: soluble

solubility

H2O: 10 mg/mL, clear, DMSO: 5 mg/mL, clear (warmed)

Application

Pharmacological activity investigating:
  • The drug effects on metabolization[1]
  • In vitro cytochrome P450 activity in microsomes[2]

Analyte for electron-capture gas chromatography procedures[3]

General description

CYP2C19 metabolite of mephenytoin.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000439380
0000439380
0000199199
0000155063
0000150354

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Sonja Krösser et al.
European journal of clinical pharmacology, 62(4), 277-284 (2006-03-10)
The 5HT(1A) receptor agonist sarizotan is in clinical development for the treatment of dyskinesia, a potentially disabling complication in Parkinson's disease. We investigated the effect of sarizotan on the clinical pharmacokinetics of probe drugs for cytochrome P450 (CYP) to evaluate
M. Salsali, et al.,
Journal of Pharmacological and Toxicological Methods, 44, 461-465 (2001)
A Adedoyin et al.
Clinical pharmacology and therapeutics, 64(1), 8-17 (1998-08-08)
Drug metabolism is influenced by liver disease because of the central role that the liver plays in metabolic activities in the body. However, it is still unclear how activities of specific drug-metabolizing enzymes are influenced by the presence and severity
M Tanaka et al.
Clinical pharmacology and therapeutics, 62(6), 619-628 (1998-01-20)
To assess the possible relationship between the metabolic disposition of pantoprazole and genetically determined S-mephenytoin 4'-hydroxylation phenotype and genotype. The pharmacokinetic disposition of pantoprazole was investigated in 14 Japanese male volunteers (seven extensive and seven poor metabolizers of S-mephenytoin). All
C Desiderio et al.
Electrophoresis, 15(1), 87-93 (1994-01-01)
Using cyclodextrin micellar electrokinetic capillary chromatography (CD-MECC), baseline separation of mephenytoin, 4-hydroxymephenytoin and 4-hydroxyphenytoin enantiomers in urine was effected with beta-cyclodextrin. After single-dose administration of 100 mg of racemic mephenytoin, the 0-8 h urine was collected, and enzymatically hydrolyzed urine
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