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Sigma-Aldrich

KitAlysis High-Throughput Miyaura Borylation Reaction Screening Kit-Pack of 2

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reaction suitability

reagent type: catalyst
core: palladium
reaction type: Miyaura Borylation Reaction

functional group

phosphine

General description

The KitAlysis High-Throughput Miyaura Borylation Reaction Screening Kit enables chemists to quickly and efficiently screen reaction conditions for Pd catalyzed Miyaura borylation reactions. Quick identification of optimal conditions allows faster scale-up of the desired synthetic transformation. All required chemicals come pre-weighed for ease of use. A step-by-step user guide and experimental excel sheets are available for download to facilitate the process.

Application

Step-by-step user guides and a downloadable experimental excel sheets are provided in the below hyperlinks.
Step-by-Step Guide for Miyaura Borylation Reaction Screening Kit
Downloadable Experiment excel sheets

Each kit contains 2 customizable screening sets that include the following components:

  • 6 x 4 pre-weighed catalysts in glass vials loaded with stir bars and topped with cap mat.
  • 4 x 4 mL reaction vials with pre-weighed KOAc
  • Bis(pinacolato)diboron (473294), tetrahydroxydiboron (754242), and pinacol (221171)
  • 1 (2 mL) ampule each of toluene, THF, n-butanol, DMA, MeOH, MeCN, ethylene glycol and DIPEA.
  • 1 NEW KitAlysis 24-Well Reaction Block Replacement Film.
  • 4 stir bars for substrate stock solution vials.
  • 1 internal standard.
Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

  • Designed and tested by synthetic chemists.
  • Easily run 24-microscale reactions in parallel.
  • 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration.
  • Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks.

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Kit Components Also Available Separately

Product No.
Description
SDS

  • 764175P(Cy3) Pd G3, 97%SDS

  • 791733Potassium acetate, anhydrous, free-flowing, Redi-Dri, ACS reagent, ≥99.0%SDS

  • 804274XPhos Pd G4, 95%SDS

  • 804282SPhos Pd G4SDS

  • 804290RuPhos Pd G4SDS

  • 804975DTBPF-Pd-G3SDS

  • 900349cataCXium Pd G4SDS

  • 900522Toluene, anhydrous, ZerO2®, 99.8%SDS

  • 900631Ethylene glycol, anhydrous, ZerO2®, 99.8%SDS

  • 900634N,N-Dimethylacetamide, anhydrous, ZerO2®, 99.8%SDS

  • 900636Tetrahydrofuran, anhydrous, inhibitor-free, ZerO2®, ≥99.9%SDS

  • 9006391-Butanol, anhydrous, ZerO2®, 99.8%SDS

  • 900641Methanol, anhydrous, ZerO2®, 99.8%SDS

  • 900644Acetonitrile, anhydrous, ZerO2®, 99.8%SDS

  • 900690N,N-Diisopropylethylamine, purified by redistillation, ZerO2®, 99.5%SDS

  • 221171Pinacol, 98%SDS

  • 473294Bis(pinacolato)diboron, 99%SDS

  • 754242Tetrahydroxydiboron, 95%SDS

  • B34656Biphenyl, ReagentPlus®, 99.5%SDS

  • Z118850Spinbar® magnetic stirring fleas, red, L 10 mm, diam. 3 mmSDS

  • Z742110KitAlysis 24-well reaction block replacement filmSDS

See All (21)

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 2 Oral - STOT SE 1

target_organs

Kidney

supp_hazards

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

1.4 °F

flash_point_c

-17 °C


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