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KitAlysis High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4

Amination Screening Kit, Buchwald-Hartwig Amination

reaction suitability

reaction type: Buchwald-Hartwig Amination
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Cross Couplings
reagent type: catalyst
core: palladium

storage temp.

room temp


Screening kit for CN (Buchwald-Hartwig) cross-coupling reaction. There are four possible screens that can be run based upon the user’s substrates. Step-by-step user guides and a downloadable experimental excel sheets for each screen is provided in the below hyperlinks.

Two Solvents, Weak Base (Cs2CO3)
Download the experimental excel file here
Two Solvents, Strong Base (NaOt-Bu)
Download the experimental excel file here
One Solvent (Dioxane), Two Bases
Download the experimental excel file here
One Solvent (DMAc), Two Bases
Download the experimental excel file here

Each kit contains 4 screening sets that contain the following:
Each customizable screening kit contains

  • 12 X 2 pre-weighed catalysts (1 μmol) in individual microvials with magnetic stir bars
  • 2 bases (NaOt-Bu and Cs2CO3)
  • 2 degassed anhydrous solvents (dioxane and DMAc) in ampules
  • 2 substrate reaction vials with stir bars
  • 1 internal standard
  • 4 reaction block replacement films
Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

  • Designed and tested by synthetic chemists
  • Easily run 24-microscale reaction in parallel
  • 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration
  • Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Kit Components Only

Product No.

  • SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA

Kit Components Also Available Separately

Product No.

  • 900634N,N-Dimethylacetamide, anhydrous, ZerO2®, 99.8% 8 mLSDS

  • 9006401,4-Dioxane, anhydrous, ZerO2®, 99.8% 8 mLSDS

  • 702706Sodium tert-butoxide solution, 2 M in THF, ZerO2® 4 mLSDS

  • 747130Josiphos SL-J009-1 Pd G3 5 µmolSDS

  • 753009SPhos Pd G2 5 µmolSDS

  • 753246RuPhos Pd G2 5 µmolSDS

  • 756482P(t-Bu)3 Pd G2 5 µmolSDS

  • 761605BrettPhos Pd G3, 98% 5 µmolSDS

  • 762229tBuXPhos Pd G3, 98% 5 µmolSDS

  • 763004CPhos Pd G3, 95% 5 µmolSDS

  • 763039XantPhos Pd G3, 95% 5 µmolSDS

  • 763381XPhos Pd G3, 98%, 1:1 MTBE adduct 5 µmolSDS

  • 792357MorDalphos Pd G3 5 µmolSDS

  • 804959DavePhos-Pd-G3, 95% 5 µmolSDS

  • 804967rac-BINAP-Pd-G3, 95% 5 µmolSDS

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Signal Word


Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Dam. 1 - Repr. 1B - Self-heat. 1 - Skin Corr. 1B - STOT RE 2 Oral

Supplementary Hazards



Flash Point(F)

-4.0 °F - closed cup

Flash Point(C)

-20 °C - closed cup

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

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