≥98% (HPLC)

1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one, DuP 996
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
MDL number:
PubChem Substance ID:

Quality Level


≥98% (HPLC)


white to off-white


DMSO: >10 mg/mL
ethanol: 240 mg/mL

SMILES string




InChI key


Gene Information


10, 50 mg in glass bottle

Biochem/physiol Actions

Stimulates release of acetylcholine and other neurotransmitters; cognitive enhancer.

Legal Information

Sold under exclusive license from DuPont.


13 - Non Combustible Solids

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Chin-Wei Huang et al.
The international journal of neuropsychopharmacology, 11(5), 597-610 (2008-01-11)
Oxcarbazepine (OXC), one of the newer anti-epileptic drugs, has been demonstrating its efficacy on wide-spectrum neuropsychiatric disorders. However, the ionic mechanism of OXC actions in neurons remains incompletely understood. With the aid of patch-clamp technology, we first investigated the effects...
Olga Zavaritskaya et al.
Hypertension (Dallas, Tex. : 1979), 61(1), 151-159 (2012-11-28)
KCNQ channels have been identified in arterial smooth muscle. However, their role in vasoregulation and chronic vascular diseases remains elusive. We tested the hypothesis that KCNQ channels contribute to periadventitial vasoregulation in peripheral skeletal muscle arteries by perivascular adipose tissue...
Alexander R Mackie et al.
The Journal of pharmacology and experimental therapeutics, 325(2), 475-483 (2008-02-15)
Pressor effects of the vasoconstrictor hormone arginine vasopressin (AVP), observed when systemic AVP concentrations are less than 100 pM, are important for the physiological maintenance of blood pressure, and they are also the basis for therapeutic use of vasopressin to...
Richardson N Leão et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(42), 13353-13364 (2009-10-23)
While the synaptic mechanisms involved in the generation of in vitro network oscillations have been widely studied, little is known about the importance of voltage-gated currents during such activity. Here we study the role of the M-current (I(M)) in the...
S Y M Yeung et al.
British journal of pharmacology, 151(6), 758-770 (2007-05-24)
This study represents a novel characterisation of KCNQ-encoded potassium channels in the vasculature using a variety of pharmacological and molecular tools to determine their role in contractility. Reverse transcriptase polymerase chain reaction (RT-PCR) experiments were undertaken on RNA isolated from...

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