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1-Phenylbiguanide hydrochloride


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244-247 °C (lit.)

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Colleen J Thomas et al.
Clinical and experimental pharmacology & physiology, 38(7), 410-415 (2011-04-15)
1. Cardiac natriuretic peptides act on cardiopulmonary chemoreceptor afferents to enhance the von Bezold-Jarisch reflex (BJR). Activity of the natriuretic peptide particulate guanylyl cyclase receptor is essential for full expression of the BJR. Whether natriuretic peptides act directly on cardiac
Florence Netzer et al.
The European journal of neuroscience, 29(10), 2017-2028 (2009-05-21)
Stimulation of the dorsolateral periaqueductal gray matter (dlPAG) and the B3 cell group inhibits the cardiovagal component of the baroreflex in rats. Our aim was to determine whether the defence reaction induces similar modulatory effects on the cardiac response of
John Eme et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 181(7), 981-990 (2011-03-30)
Hypoxia is a naturally occurring environmental challenge for embryonic non-avian reptiles, and this study is the first to investigate the impact of chronic hypoxia on a possible chemoreflex loop in a developing non-avian reptile. We measured heart rate and blood
Debra I Diz et al.
Journal of cardiovascular pharmacology, 51(6), 542-548 (2008-05-14)
Endogenous angiotensin (Ang)-(1-7) enhances, while Ang II attenuates, baroreceptor sensitivity (BRS) for reflex control of heart rate (HR) in Sprague-Dawley (SD) rats. In (mRen2)27 renin transgenic rats [(mRen2)], there is overexpression of the mouse Ren2 gene in brain, leading to
Domitila A Huber et al.
The Journal of physiology, 588(Pt 9), 1515-1525 (2010-03-10)
Adult obese Zucker rats (OZRs) have reduced sympathetic responses to evoked changes in arterial pressure (AP) compared to lean Zucker rats (LZRs). This study examined whether attenuated sympathetic baroreflexes in OZRs may be due to altered sensory or central mechanisms.

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