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Q0750

Sigma-Aldrich

Quinidine hydrochloride monohydrate

technical grade

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Synonym(s):
6′-Methoxycinchonan-9-ol hydrochloride monohydrate
Empirical Formula (Hill Notation):
C20H24N2O2 · HCl · H2O
CAS Number:
Molecular Weight:
378.89
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

grade

technical grade

impurities

≤20% Dihydroquinidine (according to USP specifications., actual content given on label)

SMILES string

O.Cl.[H][C@@]1(C[C@@H]2CC[N@H]1C[C@@H]2C=C)[C@@H](O)c3ccnc4ccc(OC)cc34

InChI

1S/C20H24N2O2.ClH.H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;1H2/t13-,14-,19+,20-;;/m0../s1

InChI key

SGVZDMWHXVXUBY-KAIFKDDSSA-N

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This Item
226322263022600
Quinidine crystallized, ≥98.0% (dried material, NT)

Sigma-Aldrich

22600

Quinidine

grade

technical grade

grade

-

grade

-

grade

-

impurities

≤20% Dihydroquinidine (according to USP specifications., actual content given on label)

impurities

-

impurities

≤10% dihydroquinine hydrochloride (HPLC)

impurities

≤2% water, ~10% hydroquinidine (HPLC)

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Gene Information

-

Gene Information

-

Gene Information

human ... ABCB1(5243), CYP2D6(1565), CYP3A4(1576), KCNH1(3756), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
mouse ... Abcb1a(18671), Abcb1b(18669)
rat ... Cyp2d1(266684), Cyp2d2(25053), Cyp2d3(24303), Cyp2d4v1(171522)

Application

Studied for pharmacological activity causing energy shifts from mitochondrial respiration to glycolysis

Biochem/physiol Actions

Class IA antiarrhythmic; potassium channel blocker.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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