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QBD10011

Sigma-Aldrich

Phthalimidooxy-dPEG®4-NHS ester

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100 MG
$136.00
1000 MG
$1,040.00

$136.00

Estimated to ship onJune 16, 2025Details

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100 MG
$136.00
1000 MG
$1,040.00

About This Item

Empirical Formula (Hill Notation):
C23H28N2O11
Molecular Weight:
508.48
MDL number:
MFCD28155511
UNSPSC Code:
12352108
PubChem Substance ID:
329823874
NACRES:
NA.22

$136.00

Estimated to ship onJune 16, 2025Details

Request a Bulk Order

assay

>90%

form

solid or viscous liquid

reaction suitability

reactivity: amine reactive
reagent type: cross-linking reagent
reactivity: thiol reactive

functional group

NHS ester

polymer architecture

shape: linear
functionality: heterobifunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCON2C(C(C=CC=C3)=C3C2=O)=O

InChI

1S/C23H28N2O11/c26-19-5-6-20(27)24(19)36-21(28)7-8-31-9-10-32-11-12-33-13-14-34-15-16-35-25-22(29)17-3-1-2-4-18(17)23(25)30/h1-4H,5-16H2

InChI key

HLAGLPXQSIDIDX-UHFFFAOYSA-N

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Phthalimidooxy-dPEG®4-NHS ester

QBD10011

Phthalimidooxy-dPEG®4-NHS ester

SPDP-dPEG®8-NHS ester

QBD10376

SPDP-dPEG®8-NHS ester

Phthalimidooxy-dPEG®12-NHS ester

QBD11135

Phthalimidooxy-dPEG®12-NHS ester

Acid-dPEG®9-NHS ester

QBD10119

Acid-dPEG®9-NHS ester

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

assay

>90%

assay

>90%

assay

>90%

assay

>90%

functional group

NHS ester

functional group

NHS ester

functional group

-

functional group

NHS ester, carboxylic acid

reaction suitability

reactivity: amine reactive, reagent type: cross-linking reagent
reactivity: thiol reactive

reaction suitability

reactivity: thiol reactive, reagent type: cross-linking reagent
reactivity: amine reactive

reaction suitability

reactivity: thiol reactive, reagent type: cross-linking reagent
reactivity: amine reactive

reaction suitability

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Features and Benefits

Phthalimidooxy-dPEG®4-NHS ester allows introduction of an oxyamine function onto a target molecule for cross-linking proteins or for creating stable conjugates with the target molecule. The oxyamine function is protected by a phthalimido protecting group on one end of the spacer arm, and the spacer is installed on the target molecule with the amine-reactive N-hydroxysuccinimide (NHS) group on the other end of the spacer. The single molecular weight dPEG® spacers have precise length for spatial control. They are hydrophilic and non-immunogenic. The dPEG® spacers improve water solubility and reduce aggregation and precipitation of proteins. The phthalimido protecting group can be removed using hydrazine. The oxyamine group exposed after deprotection can be reacted with an aldehyde- or ketone-containing molecule to form an oxime bond linking the two molecules. These reagents can be used with any protein, peptide, or small molecule that has a free amine.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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