QBD10194

NHS-S-S-dPEG^®₄-biotin (cleavable)

• Synonym(s): 2,5-Dioxo-1-pyrrolidinyl 29-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-9,25-dioxo-12,15,18,21-tetraoxa-4,5-dithia-8,24-diazanonacosanoate, Polyethylene glycol
• Empirical Formula (Hill Notation): C₃₀H₄₉N₅O₁₁S₃
• CAS Number: 1260247-51-5
• Molecular Weight: 751.93
• UNSPSC Code: 12352200
• PubChem Substance ID: 329823886
• NACRES: NA.22

Properties

• assay: >90%
• form: solid or viscous liquid
• reaction suitability: reaction type: Biotinylations; reagent type: cross-linking reagent
• functional group: disulfide
• polymer architecture: shape: linear; functionality: monofunctional
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O=C(NCCSSCCC(ON1C(CCC1=O)=O)=O)CCOCCOCCOCCOCCNC(CCCCC2C3NC(NC3CS2)=O)=O

Description

Features and Benefits

NHS-S-S-dPEG^®₄-biotin is used extensively to label molecules that contain a free amine with biotin. This dPEG^® spacer imparts a high degree of water solubility to the biotin label. For biotinylated peptides and proteins, the dPEG^® spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin. NHS-S-S-dPEG^®₄-biotin contains a disulfide group in the linear chain, allowing the biotin to be cleaved reductively from the labeled molecule.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable