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QBD10199

dPEG®4-biotin acid

>95% (HPLC)

Synonym(s):

Biotin-PEG-acid, Biotin-PEG4-COOH, Biotin-PEG4-acid, Carboxy-PEG4-biotin, PEG4-biotin acid

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100 MG

$187.00

$187.00

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About This Item

Empirical Formula (Hill Notation):
C21H37N3O8S
Molecular Weight:
491.60
NACRES:
NA.22
UNSPSC Code:
12352106

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assay

>95% (HPLC)

form

solid or viscous liquid

reaction suitability

reaction type: Biotinylations, reaction type: Pegylations

polymer architecture

shape: linear
functionality: monofunctional

shipped in

ambient

storage temp.

−20°C

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This Item
909882QBD10244689998
dPEG®4-biotin acid >95% (HPLC)

Sigma-Aldrich

QBD10199

dPEG®4-biotin acid

Biotin-poly(ethylene glycol)-b-poly(lactide-co-glycolide) PEG average Mn 2,000, PLGA average Mn 10,000, lactide:glycolide 50:50

Sigma-Aldrich

909882

Biotin-poly(ethylene glycol)-b-poly(lactide-co-glycolide)

Amino-dPEG®4-acid >95% (HPLC)

Sigma-Aldrich

QBD10244

Amino-dPEG®4-acid

O-[2-(Biotinylamino)ethyl]-O′-(2-carboxyethyl)undecaethylene glycol ≥95% (oligomer purity)

Sigma-Aldrich

689998

O-[2-(Biotinylamino)ethyl]-O′-(2-carboxyethyl)undecaethylene glycol

assay

>95% (HPLC)

assay

-

assay

>95% (HPLC)

assay

≥95% (oligomer purity)

polymer architecture

shape: linear
functionality: monofunctional

polymer architecture

-

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

-

form

solid or viscous liquid

form

powder or chunks

form

solid or viscous liquid

form

powder

reaction suitability

reaction type: Biotinylations, reaction type: Pegylations

reaction suitability

-

reaction suitability

reaction type: Pegylations

reaction suitability

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

ambient

shipped in

-

shipped in

ambient

shipped in

-

Features and Benefits

dPEG4 biotin acid consists of biotin and a propionic acid-functionalized tetraethylene glycol derivative. Numerous functional or reactive groups can modify the terminal acid moiety, including the acylating agents N-hydroxysuccinimide (NHS) and 2,3,5,6-tetrafluorophenol (TFP). Also, dPEG4 biotin acid reacts directly with primary amines using a suitable carbodiimide such as 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC). The amphiphilic dPEG linker gives biotin excellent solubility in water and aqueous buffer, where biotin usually is poorly soluble. dPEG4 biotin acid offers significantly superior solubility and performance characteristics compared to the traditional, highly hydrophobic biotinylation reagent known as LC-biotin. Moreover, although dPEG4 biotin acid and LC-biotin have comparable linker lengths, dPEG4 biotin acid will not trigger the aggregation and precipitation of conjugated biomolecules, even at high levels of biotin incorporation on the biomolecule. In contrast, LC-biotin triggers the aggregation and precipitation of biomolecules with the incorporation of a few LC-biotin groups onto the biomolecule.

Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)

Legal Information

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Alexander Kuzmin et al.
Bioconjugate chemistry, 21(11), 2076-2085 (2010-10-23)
The utility of catalyst-free azide-alkyne [3 + 2] cycloaddition for the immobilization of a variety of molecules onto a solid surface and microbeads was demonstrated. In this process, the surfaces are derivatized with aza-dibenzocyclooctyne (ADIBO) for the immobilization of azide-tagged
Amir Syahir et al.
Chemistry, an Asian journal, 7(8), 1867-1874 (2012-05-29)
The need to develop label-free biosensing devices that enable rapid analyses of interactions between small molecules/peptides and proteins for post-genomic studies has increased significantly. We report a simple metal-insulator-metal (MIM) geometry for fabricating a highly sensitive detection platform for biosensing.

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