This product contains only the dPEG4 polymer length and does not include other PEG derivative lengths, such as PEG 3 or PEG 5 isomers. Therefore, there are no additional PEG monomer lengths present in this product.
QBD10200
NHS-dPEG®4-biotin
Synonym(s):
(+)-Biotin-PEO4-NHS-propionate, NHS-PEO4-Biotin, Polyethylene glycol
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| Size/SKU | Availability | Price |
|---|---|---|
50 mg | Available to ship TODAYfromMILWAUKEE | $179.00 |
1000 mg | Available to ship TODAYfromMILWAUKEE | $1,160.00 |
About This Item
Empirical Formula (Hill Notation):
C25H40N4O10S
CAS Number:
Molecular Weight:
588.67
UNSPSC Code:
12161502
PubChem Substance ID:
NACRES:
NA.22
assay
>90%
form
solid or viscous liquid
reaction suitability
reagent type: cross-linking reagent
reaction type: Biotinylations
reactivity: amine reactive, reagent type: linker
polymer architecture
shape: linear
functionality: monofunctional
shipped in
ambient
storage temp.
−20°C
SMILES string
O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCNC(CCCCC2C3NC(NC3CS2)=O)=O
InChI
1S/C25H40N4O10S/c30-20(4-2-1-3-19-24-18(17-40-19)27-25(34)28-24)26-8-10-36-12-14-38-16-15-37-13-11-35-9-7-23(33)39-29-21(31)5-6-22(29)32/h18-19,24H,1-17H2,(H,26,30)(H2,27,28,34)/t18-,19-,24-/m0/s1
InChI key
DTLVBHCSSNJCMJ-JXQFQVJHSA-N
General description
NHS-dPEG®4-biotin is a water-soluble cross-linking reagent used in biotinylation reactions. The N-hydroxysuccinimidyl (NHS) moiety of NHS-dPEG®4-biotin forms a stable amide bond with free primary amines, such as the amines on the side chain of lysine. The biotin moiety is used in a variety of applications, including labeling, supramolecular building, affinity chromatography, pull-down assays, and the production of biotinylated antibodies.
Features and Benefits
NHS-dPEG®4-biotin is used extensively to label molecules that contain a free amine with biotin. The single molecular weight NHS-dPEG®4-biotin has a long spacer of precise length (19.2 Å) between the biotin moiety and the labeled molecule. This dPEG® spacer imparts a high degree of water solubility to the biotin label. For biotinylated peptides and proteins, the dPEG® spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin.
Legal Information
Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign
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This Item | |||
|---|---|---|---|
| polymer architecture shape: linear | polymer architecture shape: linear | polymer architecture shape: linear | polymer architecture shape: linear |
| form solid or viscous liquid | form solid or viscous liquid | form solid or viscous liquid | form solid or viscous liquid |
| assay >90% | assay >90% | assay >90% | assay >90% |
| reaction suitability reagent type: cross-linking reagent | reaction suitability - | reaction suitability reagent type: cross-linking reagent | reaction suitability reagent type: cross-linking reagent |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| shipped in ambient | shipped in ambient | shipped in ambient | shipped in ambient |
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Are there other peg derivative lengths present beside the dPEG4 polymer length in the product? For example, are there PEG 3 or PEG5 isomers? If other peg monomer lengths are present, what is the general percent amount present?
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