QBD10502

Azido-dPEG^®₄-acid

• Empirical Formula (Hill Notation): C₁₁H₂₁N₃O₆
• CAS Number: 1257063-35-6
• Molecular Weight: 291.30
• MDL number: MFCD12406155
• PubChem Substance ID: 329823931
• NACRES: NA.22

Properties

• assay: >90%
• form: solid or viscous liquid
• reaction suitability: reaction type: click chemistry; reagent type: cross-linking reagent; reaction type: click chemistry
• polymer architecture: shape: linear; functionality: heterobifunctional
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: OC(CCOCCOCCOCCOCCN=[N+]=[N-])=O

Description

Features and Benefits

The azido-dPEG^®₄ contains an azide function on one end of a single molecular weight dPEG^® spacer (17.7 Å) and a reactive group on the other end of the spacer. The dPEG^® spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target. The acid function may be activated with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) or N,N′-dicyclohexylcarbodiimide (DCC) for conjugation to an amine. The azide group reacts with an alkyne in the well-known click chemistry reaction. The click chemistry reaction proceeds by copper(I) or ruthenium catalysis or in a strain-catalyzed reaction with certain types of alkyne partners.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• RIDADR: NONH for all modes of transport
• WGK Germany: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable