QBD10513

Azido-dPEG^®₁₂-acid

• Synonym(s): Polyethylene glycol, alpha-(2-azidoethyl)-omega-(2-carboxyethoxy)poly(oxy-1,2-ethanediyl)
• Empirical Formula (Hill Notation): C₂₇H₅₃N₃O₁₄
• CAS Number: 1167575-20-3
• Molecular Weight: 643.72
• MDL number: MFCD21363301
• UNSPSC Code: 12352106
• PubChem Substance ID: 329823935
• NACRES: NA.22

Properties

• assay: >90%
• form: solid or viscous liquid
• reaction suitability: reaction type: click chemistry; reagent type: cross-linking reagent; reaction type: click chemistry
• polymer architecture: shape: linear; functionality: heterobifunctional
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O
• InChI: 1S/C27H53N3O14/c28-30-29-2-4-34-6-8-36-10-12-38-14-16-40-18-20-42-22-24-44-26-25-43-23-21-41-19-17-39-15-13-37-11-9-35-7-5-33-3-1-27(31)32/h1-26H2,(H,31,32)
• InChI key: DYFODOGACDHUBQ-UHFFFAOYSA-N

Description

Features and Benefits

The azido-dPEG^®₁₂ contains an azide function on one end of a single molecular weight dPEG^® spacer (46.4 Å) and a reactive group on the other end of the spacer. The dPEG^® spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target. The reactive acid functional group may be activated with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) or N,N′-dicyclohexylcarbodiimide (DCC) for conjugation to an amine. The azide group reacts with an alkyne in the well-known click chemistry reaction. The click chemistry reaction proceeds by copper(I) or ruthenium catalysis or in a strain-catalyzed reaction with certain types of alkyne partners.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable