QBD10525

Azido-dPEG^®₂₃-amine

• Synonym(s): Polyethylene glycol
• Empirical Formula (Hill Notation): C₄₈H₉₈N₄O₂₃
• Molecular Weight: 1099.30
• UNSPSC Code: 12352116
• PubChem Substance ID: 329823939
• NACRES: NA.22
• MDL number: MFCD18427349

Properties

• assay: >90%
• form: solid or viscous liquid
• reaction suitability: reaction type: click chemistry, reagent type: cross-linking reagent; reaction type: click chemistry
• polymer architecture: shape: linear; functionality: heterobifunctional
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
• InChI: 1S/C48H98N4O23/c49-1-3-53-5-7-55-9-11-57-13-15-59-17-19-61-21-23-63-25-27-65-29-31-67-33-35-69-37-39-71-41-43-73-45-47-75-48-46-74-44-42-72-40-38-70-36-34-68-32-30-66-28-26-64-24-22-62-20-18-60-16-14-58-12-10-56-8-6-54-4-2-51-52-50/h1-49H2
• InChI key: MUYDHNADYGGZNC-UHFFFAOYSA-N

Description

General description

Azido-dPEG^®₂₃-amine is a biocompatible crosslinking reagent used in copper(I)/ruthenium catalyzed, and strain-promoted click chemistry reactions.

Features and Benefits

The azido-dPEG^®₂₃-amine contains an azide function on one end of a single molecular weight dPEG^® spacer (86.8 Å) and a reactive group on the other end of the spacer. The dPEG^® spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target. The primary amine reacts with acids and active esters. The azide group reacts with an alkyne in the well-known click chemistry reaction. The click chemistry reaction proceeds by copper(I) or ruthenium catalysis or in a strain-catalyzed reaction with certain types of alkyne partners.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable