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QBD10551

Sigma-Aldrich

MAL-dPEG®4-TFP ester

Synonym(s):

Polyethylene glycol

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About This Item

Empirical Formula (Hill Notation):
C24H28F4N2O9
Molecular Weight:
564.48
MDL number:
MFCD28505515
UNSPSC Code:
12352108
PubChem Substance ID:
329823940
NACRES:
NA.22
Pricing and availability is not currently available.

assay

>90%

form

solid or viscous liquid

reaction suitability

reactivity: thiol reactive
reagent type: cross-linking reagent
reactivity: amine reactive

functional group

ester
maleimide

polymer architecture

shape: linear
functionality: heterobifunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(NCCOCCOCCOCCOCCC(OC1=C(F)C(F)=CC(F)=C1F)=O)CCN2C(C=CC2=O)=O

InChI

1S/C24H28F4N2O9/c25-16-15-17(26)23(28)24(22(16)27)39-21(34)4-7-35-9-11-37-13-14-38-12-10-36-8-5-29-18(31)3-6-30-19(32)1-2-20(30)33/h1-2,15H,3-14H2,(H,29,31)

InChI key

LKZRDWRFDOPKGN-UHFFFAOYSA-N

Features and Benefits

MAL-dPEG®4-TFP ester is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG® spacer arm and an amine-reactive active ester on the other end. The number following the dPEG® refers to the exact number of spacer units present in the spacer arm. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. The 2,3,5,6-tetrafluorophenyl (TFP) ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Questions

  1. What are the optical properties (e.g., refractive index) of MAL-dPEG-4-TFP Ester?

    1 answer

    1. The optical properties, such as refractive index, have not been investigated. See the links below for additional references provided by the manufacturer:

      Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

      An Investigation of Phosphorous-Based Bioconjugation Techniques for Protein Modification. Maja Lopandic. UWSPACE. 2022. April 7, 2022. http://hdl.handle.net/10012/18138.

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