QBD10554

MAL-dPEG^®₂₄-TFP ester

• Empirical Formula (Hill Notation): C₆₄H₁₀₈F₄N₂O₂₉
• Molecular Weight: 1445.53
• UNSPSC Code: 12352108
• PubChem Substance ID: 329823943
• NACRES: NA.22
• MDL number: MFCD28505512

Properties

• assay: >90%
• form: solid or viscous liquid
• reaction suitability: reactivity: thiol reactive, reagent type: cross-linking reagent; reactivity: amine reactive
• polymer architecture: shape: linear; functionality: heterobifunctional
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O=C(OC1=C(C(F)=CC(F)=C1F)F)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O
• InChI key: ROVWSNWDFQZUAW-UHFFFAOYSA-N

Description

Features and Benefits

MAL-dPEG^®₂₄-TFP esters is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG^® spacer arm and an amine-reactive active ester on the other end. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. 2,3,5,6-tetrafluorophenyl (TFP) ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG^® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG^® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable