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QBD10918

Sigma-Aldrich

m-dPEG®48-amine

>95% (HPLC)

Synonym(s):
mPEG2000-amine, m-PEG48-amine, mPEG-amine, mPEG48-NH2
Empirical Formula (Hill Notation):
C97H197NO48
Molecular Weight:
2145.58
MDL number:

assay

>95% (HPLC)

form

solid or viscous liquid

reaction suitability

reaction type: Pegylations

polymer architecture

shape: linear
functionality: monofunctional

shipped in

ambient

storage temp.

−20°C

Inchi Code

1S/C97H197NO48/c1-99-4-5-101-8-9-103-12-13-105-16-17-107-20-21-109-24-25-111-28-29-113-32-33-115-36-37-117-40-41-119-44-45-121-48-49-123-52-53-125-56-57-127-60-61-129-64-65-131-68-69-133-72-73-135-76-77-137-80-81-139-84-85-141-88-89-143-92-93-145-96-97-146-95-94-144-91-90-142-87-86-140-83-82-138-79-78-136-75-74-134-71-70-132-67-66-130-63-62-128-59-58-126-55-54-124-51-50-122-47-46-120-43-42-118-39-38-116-35-34-114-31-30-112-27-26-110-23-22-108-19-18-106-15-14-104-11-10-102-7-6-100-3-2-98/h2-98H2,1H3

InChI key

NCWDZRVHWBSGGG-UHFFFAOYSA-N

Features and Benefits

m-dPEG48-amine is a methyl-terminated PEG amine compound. The PEG is a water-soluble, single molecular weight PEG product with a discrete chain length (dPEG). This dPEG linker is 146 atoms (173.1 Å) long, a monodisperse equivalent of a PEG2000. Carboxylic acids and their active esters react with the amino terminus to form amide bonds. Also, the amino terminus reacts with aldehydes and ketones, forming Schiff bonds, which are reducible to secondary amines. Uses for m-dPEG48-amine include modification of acid-functionalized surfaces and free carboxylic acid groups on biomolecules.

Legal Information

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

George Badescu et al.
Bioconjugate chemistry, 25(3), 460-469 (2014-02-12)
Many clinically used protein therapeutics are modified to increase their efficacy. Example modifications include the conjugation of cytotoxic drugs to monoclonal antibodies or poly(ethylene glycol) (PEG) to proteins and peptides. Monothiol-specific conjugation can be efficient and is often accomplished using...

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