QBD11451

Sigma-Aldrich

MAL-dPEG®12-Tris(-dPEG®24-acid)3

>90% (HPLC)

Synonym(s):
MAL-PEG12-Tris(-PEG24-acid)3, MAL-PEG600-Tris(PEG1200-COOH)3, Branched carboxy-PEG-maleimide, Branched Maleimide-PEG-acid
Empirical Formula (Hill Notation):
C200H384N6O100
Molecular Weight:
4473.17

assay

>90% (HPLC)

form

solid or viscous liquid

reaction suitability

reaction type: Pegylations

polymer architecture

functionality: monofunctional

shipped in

ambient

storage temp.

−20°C

Inchi Code

1S/C200H384N6O100/c207-190(3-15-206-195(212)1-2-196(206)213)201-11-23-224-31-39-232-47-55-240-63-71-248-79-87-256-95-103-264-111-107-260-99-91-252-83-75-244-67-59-236-51-43-228-35-27-220-16-7-194(211)205-200(187-304-17-4-191(208)202-12-24-225-32-40-233-48-56-241-64-72-249-80-88-257-96-104-265-112-118-271-124-130-277-136-142-283-148-154-289-160-166-295-172-178-301-184-181-298-175-169-292-163-157-286-151-145-280-139-133-274-127-121-268-115-108-261-100-92-253-84-76-245-68-60-237-52-44-229-36-28-221-20-8-197(214)215,188-305-18-5-192(209)203-13-25-226-33-41-234-49-57-242-65-73-250-81-89-258-97-105-266-113-119-272-125-131-278-137-143-284-149-155-290-161-167-296-173-179-302-185-182-299-176-170-293-164-158-287-152-146-281-140-134-275-128-122-269-116-109-262-101-93-254-85-77-246-69-61-238-53-45-230-37-29-222-21-9-198(216)217)189-306-19-6-193(210)204-14-26-227-34-42-235-50-58-243-66-74-251-82-90-259-98-106-267-114-120-273-126-132-279-138-144-285-150-156-291-162-168-297-174-180-303-186-183-300-177-171-294-165-159-288-153-147-282-141-135-276-129-123-270-117-110-263-102-94-255-86-78-247-70-62-239-54-46-231-38-30-223-22-10-199(218)219/h1-2H,3-189H2,(H,201,207)(H,202,208)(H,203,209)(H,204,210)(H,205,211)(H,214,215)(H,216,217)(H,218,219)

InChI key

MMVYMFQENSXDPL-UHFFFAOYSA-N

SMILES string

O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)NC(COCCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)(COCCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)COCC

Features and Benefits

MAL-dPEG12-Tris(-dPEG24-acid)3 is a thiol- and amine-reactive, four-arm, monodispersed PEG with one arm shorter than the other three. This product is useful for charge modulation and elimination of renal clearance in drug delivery and imaging applications, among others. The dPEG spacer length from the maleimide olefin to the carbonyl carbon on each of the three long arms is 129 atoms. The average distance from maleimide to carbonyl carbon is 80.4 Å.

Legal Information

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Haiming Ding et al.
Bioconjugate chemistry, 24(11), 1945-1954 (2013-11-02)
The tumor-associated glycoprotein-72 (TAG-72) antigen is highly overexpressed in various human adenocarcinomas and anti-TAG-72 monoclonal antibodies, and fragments are therefore useful as pharmaceutical targeting vectors. In this study, we investigated the effects of site-specific PEGylation with MW 2-4 kDa discrete...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.