QBD11487

Sigma-Aldrich

MAL-dPEG®24-Tris(-dPEG®24-Tris(m-dPEG®24)3)3

>95% (HPLC)

Synonym(s):
MAL-PEG24-Tris(-PEG24-Tris(m-PEG24)3)3, Branched Maleimide-PEG-m, Branched mPEG-maleimide, 9-arm mPEG 14K PEG1000-MAL
Empirical Formula (Hill Notation):
C704H1386N18O343
Molecular Weight:
15592.45

assay

>95% (HPLC)

form

solid or viscous liquid

reaction suitability

reaction type: Pegylations

polymer architecture

functionality: monofunctional

shipped in

ambient

storage temp.

−20°C

Inchi Code

1S/C620H1218N18O301/c1-658-72-81-684-111-94-672-60-30-622-599(640)13-47-928-586-617(587-929-48-14-600(641)623-31-61-673-95-112-685-82-73-659-2,588-930-49-15-601(642)624-32-62-674-97-114-698-143-158-720-187-202-742-231-246-764-275-290-786-319-334-808-363-378-830-407-422-852-451-466-874-495-510-896-539-553-917-571-564-906-527-520-884-483-476-862-439-432-840-395-388-818-351-344-796-307-300-774-263-256-752-219-212-730-175-168-708-131-124-686-83-74-660-3)634-611(652)25-43-667-90-107-693-138-153-715-182-197-737-226-241-759-270-285-781-314-329-803-358-373-825-402-417-847-446-461-869-491-506-892-535-550-914-579-583-925-561-546-903-517-502-881-473-458-859-429-414-837-385-370-815-341-326-793-297-282-771-253-238-749-209-194-727-165-150-705-121-104-681-69-39-631-608(649)22-56-937-595-620(635-612(653)26-44-668-91-108-694-139-154-716-183-198-738-227-242-760-271-286-782-315-330-804-359-374-826-403-418-848-447-462-870-490-505-891-534-549-913-578-582-924-560-538-895-509-494-873-465-450-851-421-406-829-377-362-807-333-318-785-289-274-763-245-230-741-201-186-719-157-142-697-113-96-671-59-29-621-598(639)12-42-638-615(656)10-11-616(638)657,596-938-57-23-609(650)632-40-70-682-105-122-706-151-166-728-195-210-750-239-254-772-283-298-794-327-342-816-371-386-838-415-430-860-459-474-882-503-518-904-547-562-926-584-580-915-551-536-893-507-492-871-463-448-849-419-404-827-375-360-805-331-316-783-287-272-761-243-228-739-199-184-717-155-140-695-109-92-669-45-27-613(654)636-618(589-931-50-16-602(643)625-33-63-675-98-115-699-144-159-721-188-203-743-232-247-765-276-291-787-320-335-809-364-379-831-408-423-853-452-467-875-496-511-897-540-554-918-572-565-907-528-521-885-484-477-863-440-433-841-396-389-819-352-345-797-308-301-775-264-257-753-220-213-731-176-169-709-132-125-687-84-75-661-4,590-932-51-17-603(644)626-34-64-676-99-116-700-145-160-722-189-204-744-233-248-766-277-292-788-321-336-810-365-380-832-409-424-854-453-468-876-497-512-898-541-555-919-573-566-908-529-522-886-485-478-864-441-434-842-397-390-820-353-346-798-309-302-776-265-258-754-221-214-732-177-170-710-133-126-688-85-76-662-5)591-933-52-18-604(645)627-35-65-677-100-117-701-146-161-723-190-205-745-234-249-767-278-293-789-322-337-811-366-381-833-410-425-855-454-469-877-498-513-899-542-556-920-574-567-909-530-523-887-486-479-865-442-435-843-398-391-821-354-347-799-310-303-777-266-259-755-222-215-733-178-171-711-134-127-689-86-77-663-6)597-939-58-24-610(651)633-41-71-683-106-123-707-152-167-729-196-211-751-240-255-773-284-299-795-328-343-817-372-387-839-416-431-861-460-475-883-504-519-905-548-563-927-585-581-916-552-537-894-508-493-872-464-449-850-420-405-828-376-361-806-332-317-784-288-273-762-244-229-740-200-185-718-156-141-696-110-93-670-46-28-614(655)637-619(592-934-53-19-605(646)628-36-66-678-101-118-702-147-162-724-191-206-746-235-250-768-279-294-790-323-338-812-367-382-834-411-426-856-455-470-878-499-514-900-543-557-921-575-568-910-531-524-888-487-480-866-443-436-844-399-392-822-355-348-800-311-304-778-267-260-756-223-216-734-179-172-712-135-128-690-87-78-664-7,593-935-54-20-606(647)629-37-67-679-102-119-703-148-163-725-192-207-747-236-251-769-280-295-791-324-339-813-368-383-835-412-427-857-456-471-879-500-515-901-544-558-922-576-569-911-532-525-889-488-481-867-444-437-845-400-393-823-356-349-801-312-305-779-268-261-757-224-217-735-180-173-713-136-129-691-88-79-665-8)594-936-55-21-607(648)630-38-68-680-103-120-704-149-164-726-193-208-748-237-252-770-281-296-792-325-340-814-369-384-836-413-428-858-457-472-880-501-516-902-545-559-923-577-570-912-533-526-890-489-482-868-445-438-846-401-394-824-357-350-802-313-306-780-269-262-758-225-218-736-181-174-714-137-130-692-89-80-666-9/h10-11H,12-597H2,1-9H3,(H,621,639)(H,622,640)(H,623,641)(H,624,642)(H,625,643)(H,626,644)(H,627,645)(H,628,646)(H,629,647)(H,630,648)(H,631,649)(H,632,650)(H,633,651)(H,634,652)(H,635,653)(H,636,654)(H,637,655)

InChI key

YYEIQVLNMYXSFO-UHFFFAOYSA-N

Features and Benefits

MAL-dPEG24-Tris (-dPEG24-Tris (m-dPEG24)3)3 is a sulfhydryl-reactive, multibranched, monodispersed PEG product. The product is built around tris. One arm terminates in a maleimide group that reacts selectively with free thiols in a click chemistry type of reaction. Nine branches terminate in methyl groups. The molecular weight of the product is 15,592 Daltons. The amphiphilic PEG imparts tremendous water solubility to conjugate molecules and expands their hydrodynamic volume sufficiently to eliminate the renal clearance of the conjugates. The end-to-end length of the dPEG spacer from the maleimido olefin to the terminal methyl group on each branch is 245 atoms, with an average distance of 171.2 Å.

Legal Information

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

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