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General description
N-Methylated Pomalidomide is a ligand used as a negative control for pomalidomide in the recuitment of Cereblon (CRBN) protein, whereas (S,S,S) AHPC-hydrochloride is a ligand used as negative control for (S,R,S)-AHPC in the recruitment of von-Hippel Lindau (VHL) protein. N-methylation of pomalidomide or the inversion of stereochemistry to yield of (S,S,S) AHPC prevents binding to CRBN and VHL proteins. These are provided at 10mg each.
Application
Useful for construction of small molecules structurally similar to PROTACs of interest but with no inherent degradation action in themselves serving as negative control.
Features and Benefits
Structural similarity to active CRBN/VHL ligands is optimal for construction of negative controls. The amino terminus in each can be used for attaching bifunctional linkers with reactions such as peptide coupling.
Other Notes
Negative Control Set part of QuicTPD™ kit
Legal Information
QuicTPD is a trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
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