T101

Gaboxadol hydrochloride

solid, ≥98% (HPLC)

• Synonym(s): 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride, THIP hydrochloride
• Empirical Formula (Hill Notation): C₆H₈N₂O₂ · HCl
• CAS Number: 85118-33-8
• Molecular Weight: 176.60
• EC Number: 285-687-7
• MDL number: MFCD00055180
• UNSPSC Code: 12352100
• PubChem Substance ID: 57654649
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white
• solubility: ethanol: 0.91 mg/mL; H₂O: 20 mg/mL
• SMILES string: Cl[H].Oc1noc2CNCCc12
• InChI: 1S/C6H8N2O2.ClH/c9-6-4-1-2-7-3-5(4)10-8-6;/h7H,1-3H2,(H,8,9);1H
• InChI key: ZDZDSZQYRBZPNN-UHFFFAOYSA-N
• Gene Information: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

Description

General description

Gaboxadol, also referred to as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a GABA site agonist. It has great affinity to the δ subunit of extrasynaptic high-affinity GABAA receptors.[1][2] Gaboxadol was first developed for the treatment of schizophrenia, epilepsy, primary insomnia[3] and Huntington′s disease. It can easily cross the blood-brain barrier and is rapidly absorbed by the body.[4]

Application

Gaboxadol hydrochloride has been used in cell migration and invasion assay to assess liver cancer cell migration.[5]

Biochem/physiol Actions

GABA_A receptor agonist.

Caution

Photosensitive

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)