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T33405

Sigma-Aldrich

Thiosemicarbazide

99%

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Synonym(s):
TSC, TSZ, Thiocarbamoyl hydrazide
Linear Formula:
NH2CSNHNH2
CAS Number:
Molecular Weight:
91.14
Beilstein/REAXYS Number:
506320
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

99%

mp

180-183 °C (dec.) (lit.)

SMILES string

NNC(N)=S

InChI

1S/CH5N3S/c2-1(5)4-3/h3H2,(H3,2,4,5)

InChI key

BRWIZMBXBAOCCF-UHFFFAOYSA-N

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1 of 4

This Item
B9100523019789050
Thiosemicarbazide 99%

T33405

Thiosemicarbazide

tert-Butyl carbazate 98%

B91005

tert-Butyl carbazate

Triethylsilane 99%

230197

Triethylsilane

Thiosemicarbazide puriss. p.a., 98%

89050

Thiosemicarbazide

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

mp

180-183 °C (dec.) (lit.)

mp

39-42 °C (lit.)

mp

-

mp

180-183 °C (dec.) (lit.)

Application

Thiosemicarbazide is generally condensed with aldehydes or ketones to synthesize wide range of thiosemicarbazones. It can be used to build a variety of heterocycles and bioactive molecules such as thiosemicarbazides, derivatives of thienopyrimidine urea and 2-amino thiadiazole.

pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Chronic 3

Storage Class

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Design and synthesis of thienopyrimidine urea derivatives with potential cytotoxic and pro-apoptotic activity against breast cancer cell line MCF-7.
Abdelhaleem EF, et al.
European Journal of Medicinal Chemistry, 143, 1807-1825 (2018)
Thiosemicarbazides: synthesis and reactions.
Metwally MA, et al.
Journal of Sulfur Chemistry, 32(5), 489-519 (2011)
2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents.
Klayman DL, et al.
Journal of Medicinal Chemistry, 22(7), 855-862 (1979)
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents.
Carradori S, et al.
European Journal of Medicinal Chemistry, 143, 1543-1552 (2018)
Exploiting the 2-Amino-1, 3, 4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.
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