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MilliporeSigma

W218405

Butylated hydroxytoluene

≥99%, FCC, FG

Synonym(s):

2,6-Di-tert-butyl-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC

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1 EACH

$56.90

1 KG

$98.20

10 KG

$418.00

20 KG

$565.00

$56.90


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About This Item

Linear Formula:
[(CH3)3C]2C6H2(CH3)OH
CAS Number:
Molecular Weight:
220.35
E Number:
E 321
PubChem Substance ID:
UNSPSC Code:
12164502
FEMA Number:
2184
NACRES:
NA.21
EC Number:
204-881-4
MDL number:
Beilstein/REAXYS Number:
1911640
Organoleptic:
camphoraceous
Grade:
FG, Fragrance grade, Kosher
Biological source:
synthetic
Agency:
follows IFRA guidelines
Food allergen:
no known allergens

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InChI key

NLZUEZXRPGMBCV-UHFFFAOYSA-N

InChI

1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3

SMILES string

Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C

biological source

synthetic

grade

FG, Fragrance grade, Kosher

agency

follows IFRA guidelines

reg. compliance

EU Regulation 1223/2009, EU Regulation 1333/2008 & 178/2002, FCC, FDA 21 CFR 117, FDA 21 CFR 172.115

vapor density

7.6 (vs air)

vapor pressure

<0.01 mmHg ( 20 °C)

assay

≥99%

form

powder or crystals

autoignition temp.

878 °F

bp

265 °C (lit.)

mp

69-73 °C (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

fragrance allergen

no known allergens

organoleptic

camphoraceous

Quality Level

Gene Information

human ... CAPN1(823)
rat ... Capn1(29153), Nos1(24598)

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1 of 4

This Item
1082708B12150008.17074
organoleptic

camphoraceous

organoleptic

-

organoleptic

-

organoleptic

-

grade

FG, Kosher, Fragrance grade

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

-

biological source

synthetic

biological source

-

biological source

-

biological source

-

food allergen

no known allergens

food allergen

-

food allergen

-

food allergen

-

documentation

see Safety & Documentation for available documents

documentation

-

documentation

-

documentation

-

agency

follows IFRA guidelines

agency

-

agency

-

agency

-

General description

Butylated hydroxytoluene is a synthetic phenolic compound mainly used as an antioxidant and preservative in the food industry.[1][2] It is used to prevent the lipid oxidation in oils and fat-containing foods.[3]

Application


  • Role of odorant binding protein C12 in the response of Tribolium castaneum to chemical agents.: This article explores the impact of BHT on insect biochemistry, specifically how it affects the binding affinity of odorant-binding proteins in pests, providing insights into developing more effective pest control strategies (Wang et al., 2024).

  • A novel arylpiperazine derivative (LQFM181) protects against neurotoxicity induced by 3-nitropropionic acid in in vitro and in vivo models.: Research includes BHT as a comparative standard in studying neuroprotective agents, underscoring its role in biochemical pathways related to oxidative stress and neuroprotection (Campos et al., 2024).

  • Simultaneous Determination of Fipronil, Permethrin and their Key Related Substances in a Topical Drug Product by a Single Stability Indicating High Performance Liquid Chromatography Method.: BHT is used as an internal standard to assess the stability and integrity of pharmaceutical products, demonstrating its utility in pharmaceutical analysis (Rathnasekara et al., 2024).

  • Pyrano[2,3-c]pyrazole fused spirooxindole-linked 1,2,3-triazoles as antioxidant agents: Exploring their utility in the development of antidiabetic drugs via inhibition of a-amylase and DPP4 activity.: This study utilizes BHT as a reference antioxidant to compare the efficacy of newly synthesized compounds, providing a benchmark in antioxidant research for diabetes treatment (Chahal et al., 2024).

pictograms

Environment

signalword

Warning

hcodes

Hazard Classifications

Aquatic Chronic 1

Storage Class

11 - Combustible Solids

flash_point_f

260.6 °F - open cup

flash_point_c

127 °C - open cup

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives
Williams GM, et al.
Food And Chemical Toxicology, 37(9), 1027-1038 (1999)
Burdock GA
Encyclopedia of Food and Color Additives, 1, 327-330 (1997)
Silvia Carvajal et al.
Scientific reports, 9(1), 12848-12848 (2019-09-08)
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, ranging from steatosis to non-alcoholic steatohepatitis (NASH). Recently, cerium oxide nanoparticles (CeO2NPs) have emerged as a new antioxidant agent with hepatoprotective properties in experimental liver
Safety aspects of food preservatives
Parke DV & Lewis DFV
Food Additives and Contaminants, 9(5), 561-577 (1992)
A M Vijesh et al.
European journal of medicinal chemistry, 46(11), 5591-5597 (2011-10-05)
In the present study two new series of Hantzsch 1,4-dihydropyridine derivatives (1,4-DHPs) containing substituted pyrazole moiety (4a-f and 5a-f) were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes with 1,3-dicarbonylcompounds (ethylacetoacetate and methylacetoacetate) and ammonium acetate. The newly synthesized compounds were characterized

Articles

Evolving definitions and debates around ultra-processed foods and their health effects are reshaping dietary guidelines and consumer behavior.

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Questions

1–6 of 6 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  4. How much Butylated hydroxytoluene will I receive in the sample size of Product W218405?

    1 answer
    1. For current sizing, pricing, and availability please contact our Flavors and Fragrances Customer Service at 1-800-227-4563.

      Helpful?

  5. What is Product W218405, Butylated hydroxytoluene soluble in?

    1 answer
    1. Butylated hydroxytoluene is soluble in Ethanol at 100 mg/ml and sonication may be needed. This compound is practically insoluble in water, but freely soluble in vegetable oils, acetone, chloroform and ether.

      Helpful?

  6. How should Product W218405, Butylated hydroxytoluene be stored?

    1 answer
    1. We recommend storing this product at room temperature.

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