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W222402

Sigma-Aldrich

Caffeine

anhydrous, 99%, FCC, FG

Synonym(s):
1,3,7-Trimethylxanthine
Empirical Formula (Hill Notation):
C8H10N4O2
CAS Number:
Molecular Weight:
194.19
FEMA Number:
2224
Beilstein:
17705
EC Number:
Council of Europe no.:
11741
MDL number:
PubChem Substance ID:
Flavis number:
16.016
NACRES:
NA.21

biological source

synthetic

Quality Level

grade

FG
Halal
Kosher
anhydrous

reg. compliance

EU Regulation 1334/2008 & 178/2002
FCC
FDA 21 CFR 182.1180

Assay

99%

form

powder

mp

234-236.5 °C (lit.)

solubility

H2O: soluble 18.7 g/L at 16 °C

application(s)

flavors and fragrances

Documentation

see Safety & Documentation for available documents

food allergen

no known allergens

Organoleptic

odorless

SMILES string

CN1C(=O)N(C)c2ncn(C)c2C1=O

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

InChI key

RYYVLZVUVIJVGH-UHFFFAOYSA-N

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This Item
C7731C075056396
Caffeine anhydrous, 99%, FCC, FG

Sigma-Aldrich

W222402

Caffeine

Caffeine meets USP testing specifications, anhydrous

Sigma-Aldrich

C7731

Caffeine

Caffeine powder, ReagentPlus®

Sigma-Aldrich

C0750

Caffeine

Caffeine certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

56396

Caffeine

biological source

synthetic

biological source

-

biological source

-

biological source

-

grade

FG, Halal, Kosher, anhydrous

grade

anhydrous

grade

-

grade

certified reference material, TraceCERT®

assay

99%

assay

-

assay

-

assay

-

mp

234-236.5 °C (lit.)

mp

234-236.5 °C (lit.)

mp

234-236.5 °C (lit.)

mp

234-236.5 °C (lit.)

documentation

see Safety & Documentation for available documents

documentation

-

documentation

-

documentation

-

food allergen

no known allergens

food allergen

-

food allergen

-

food allergen

-

General description

Caffeine is an addictive psychoactive compound, consumed mostly in the form of brewed coffee, instant coffee, tea and caffeinated soft drinks. Caffeine is reported to be an allergen and causes anaphylaxis. It is added to common analgesics such as paracetamol, ibuprofen and aspirin for enhancing their analgesic efficacy.

Biochem/physiol Actions

A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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