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W290904

Sigma-Aldrich

Piperine

≥95%, FG

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Synonym(s):
1-Piperoylpiperidine
Empirical Formula (Hill Notation):
C17H19NO3
CAS Number:
Molecular Weight:
285.34
FEMA Number:
2909
Beilstein:
90741
EC Number:
Council of Europe no.:
492
MDL number:
PubChem Substance ID:
Flavis number:
14.003
NACRES:
NA.21

biological source

Piper nigrum L.

Quality Level

grade

FG
Halal
Kosher

reg. compliance

EU Regulation 1334/2008 & 178/2002
FDA 21 CFR 172.515

Assay

≥95%

form

powder, crystals or granules

mp

131-135 °C (lit.)

application(s)

flavors and fragrances

Documentation

see Safety & Documentation for available documents

food allergen

no known allergens

Organoleptic

fatty; pepper

SMILES string

O=C(\C=C\C=C\c1ccc2OCOc2c1)N3CCCCC3

InChI

1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+

InChI key

MXXWOMGUGJBKIW-YPCIICBESA-N

Gene Information

human ... CYP3A4(1576)

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1 of 4

This Item
P490078.21036Y0001217
Piperine ≥95%, FG

Sigma-Aldrich

W290904

Piperine

Piperine ≥97%

Sigma-Aldrich

P49007

Piperine

Piperine for synthesis

Sigma-Aldrich

8.21036

Piperine

Piperine European Pharmacopoeia (EP) Reference Standard

Y0001217

Piperine

grade

FG, Halal, Kosher

grade

-

grade

-

grade

pharmaceutical primary standard

assay

≥95%

assay

≥97%

assay

≥98.0% (HPLC)

assay

-

mp

131-135 °C (lit.)

mp

131-135 °C (lit.)

mp

127-130 °C

mp

131-135 °C (lit.)

documentation

see Safety & Documentation for available documents

documentation

-

documentation

-

documentation

-

food allergen

no known allergens

food allergen

-

food allergen

-

food allergen

-

Biochem/physiol Actions

Piperine, a major component of black pepper extracts, shown to have potential for inhibiting fat cell formation.

Pictograms

Exclamation markEnvironment

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Ui-Hyun Park et al.
Journal of agricultural and food chemistry, 60(15), 3853-3860 (2012-04-03)
This study investigated the antiadipogenic activity of black pepper extract and its constituent piperine in 3T3-L1 preadipocytes as well as the underlying molecular mechanisms. Both black pepper extract and piperine, without affecting cytotoxicity, strongly inhibited the adipocyte differentiation of 3T3-L1
Janine Zaugg et al.
Journal of natural products, 73(2), 185-191 (2010-01-21)
A plant extract library was screened for GABA(A) receptor activity making use of a two-microelectrode voltage clamp assay on Xenopus laevis oocytes. An ethyl acetate extract of black pepper fruits [Piper nigrum L. (Piperaceae) 100 microg/mL] potentiated GABA-induced chloride currents
Clara Grosso et al.
Phytochemical analysis : PCA, 24(2), 141-147 (2012-09-19)
Depression is a mental disease causing large personal and socio-economic problems, and new improved drugs are therefore needed. Selective monoamine oxidase A (MAO-A) inhibitors are potential anti-depressants, but discovering new MAO-A inhibitors from natural sources by bioassay-guided approaches are a
Hyung Gyun Kim et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(7), 2342-2348 (2012-05-01)
Piperine is a major component of black (Piper nigrum Linn) and long (Piper longum Linn) peppers, and is widely used as a traditional food and medicine. It also exhibits a variety of biological activities, which include antioxidant, anti-tumor and anti-pyretic
Hyejeong Jwa et al.
Biochemical pharmacology, 84(11), 1501-1510 (2012-09-25)
This study investigated the role of piperine in the transcriptional regulation of liver X receptor α (LXRα) and the effects of dietary piperine on high-fat diet (HFD)-induced hepatic steatosis and insulin resistance in mice. Furthermore, we explored the potential molecular

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