Polysorbate 80


POE (20) sorbitan monooleate, Polyoxyethylenesorbitan monooleate, Polyethylene glycol sorbitan monooleate, TWEEN 80, Polysorbate 80
CAS Number:
FEMA Number:
MDL number:
E Number:
E 433

Quality Level

biological source

palm oil



reg. compliance

EU Regulation 1333/2008 & 178/2002
FDA 21 CFR 172.515
FDA 21 CFR 172.836
FDA 21 CFR 172.838
FDA 21 CFR 172.840
FDA 21 CFR 172.842
FDA 21 CFR 173.340
FDA 21 CFR 175.105
FDA 21 CFR 176.180
FDA 21 CFR 178.3400
FDA 21 CFR 573.860
FDA 21 CFR 73.1001
FDA 21 CFR 73.1

vapor pressure

<1 mmHg ( 20 °C)

refractive index

n20/D 1.472 (lit.)


1.064 g/mL at 25 °C (lit.)


see Safety & Documentation for available documents

Featured Industry

Flavors and Fragrances



food allergen

no known allergens



InChI key


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General description

Polysorbate 80 (TWEEN® 80) is a polyethylene sorbitol ester. It has been tested as an efficient phase transfer catalyst for cyanation of alkyl halides, Williamson synthesis of ether and base-catalyzed dehydrobromination of alkyl halides.


Polysorbate 80 has been used in a stability study to prepare a 15% polysorbate 80-dimethyl trisulfide (DMTS-PS80) formulation, which shows promising potential in cyanide countermeasures.
Polysorbate 80 (TWEEN® 80), a hydrophilic non-ionic surfactant, is widely employed as surfactant and solubilizing agent in food, cosmetic and pharmaceutical industries.


1 kg in poly bottle
10, 25 kg in poly drum

Other Notes

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Legal Information

TWEEN is a registered trademark of Croda International PLC

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Stability characterization of a polysorbate 80-dimethyl trisulfide formulation, a cyanide antidote candidate.
Bartling CM, et al.
Drugs in R&D, 16(1), 109-127 (2016)
Hongjian Zhang et al.
Archives of pharmacal research, 26(9), 768-772 (2003-10-17)
Tween 80 (Polysorbate 80) is a hydrophilic nonionic surfactant commonly used as an ingredient in dosing vehicles for pre-clinical in vivo studies (e.g., pharmacokinetic studies, etc.). Tween 80 increased apical to basolateral permeability of digoxin in Caco-2 cells suggesting that...
Use of Polysorbate 80 (Tween 80) as a phase-transfer catalyst.
Thoman CJ, et al.
The Journal of Organic Chemistry, 54(18), 4476-4478 (1989)
Asher Preska Steinberg et al.
Biomacromolecules, 20(7), 2675-2683 (2019-06-28)
Systems consisting of a polyelectrolyte solution in contact with a cross-linked polyelectrolyte network are ubiquitous (e.g., biofilms, drug-delivering hydrogels, and mammalian extracellular matrices), yet the underlying physics governing these interactions is not well understood. Here, we find that carboxymethyl cellulose...

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