W292400

Sigma-Aldrich

Propionic acid

≥99.5%, FCC, FG

Synonym(s):
Propanyl acid, Acid C3, Propanoic acid
Linear Formula:
CH3CH2COOH
CAS Number:
Molecular Weight:
74.08
FEMA Number:
2924
Beilstein/REAXYS Number:
506071
EC Number:
Council of Europe no.:
3
MDL number:
eCl@ss:
39021305
PubChem Substance ID:
Flavis number:
8.003
NACRES:
NA.21

Quality Level

biological source

synthetic

grade

FG
Halal
Kosher

Agency/Method

follows IFRA guidelines
meets purity specifications of JECFA

reg. compliance

EU Regulation 1223/2009
EU Regulation 1334/2008 & 178/2002
FCC
FDA 21 CFR 178.1010
FDA 21 CFR 184.1081

vapor density

2.55 (vs air)

vapor pressure

2.4 mmHg ( 20 °C)

assay

≥99.5%

autoignition temp.

955 °F

expl. lim.

12.1 %

refractive index

n20/D 1.386 (lit.)

bp

141 °C (lit.)
141 °C

mp

−24-−23 °C (lit.)

solubility

H2O: soluble

density

0.993 g/mL at 25 °C (lit.)

Documentation

see Safety & Documentation for available documents

Featured Industry

Flavors and Fragrances

Organoleptic

dairy; acidic; pungent

food allergen

no known allergens

fragrance allergen

no known allergens

SMILES string

CCC(O)=O

InChI

1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)

InChI key

XBDQKXXYIPTUBI-UHFFFAOYSA-N

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General description

Propionic acid (PA) is a naturally occurring carboxylic acid, which in its pure state exists as a colorless corrosive liquid with an unpleasant odor. It is miscible in water. Industrially it is produced by hydrocarboxylation of ethylene in presence nickel carbonyl as a catalyst. PA has been found to reduce food intake, lower the fatty acids content in plasma and liver, might improve tissue insulin sensitivity and exerts immunosuppressive actions. Propionic acid is an excellent raw material as it is stable, cheap and safe and can even be used as a food additive.
Propionic acid is a volatile fatty acid (VFA) formed in the rumen of ruminants by bacterial fermentations.

Packaging

10, 25 kg in composite drum
1 kg in poly bottle

Other Notes

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Signal Word

Danger

Hazard Statements

hazcat

Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - STOT SE 3

Target Organs

Respiratory system

storage_class_code

3 - Flammable liquids

WGK Germany

WGK 1

Flash Point(F)

129.2 °F - closed cup

Flash Point(C)

54 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Metabolism of propionic acid in animal tissues I. Enzymatic conversion of propionate to succinate.
Flavin M & Ochoa S.
The Journal of Biological Chemistry, 229(2), 965-979 (1957)
Interconversions and production of volatile fatty acids in the sheep rumen.
Bergman EN, et al.
The Biochemical Journal, 97(1), 53-58 (1965)
Nucleophilic ?-Carbon Activation of Propionic Acid as a 3-Carbon Synthon by Carbene Organocatalysis
Jin, Zhichao, et al.
Chemistry?A European Journal , 21 (26), 9360-9363 (2015)
Flour and Breads and their Fortification in Health and Disease Prevention.
Victor R. Preedy, Ronald Ross Watson, Vinood B
Technology & Engineering, 476-476 (2011)
Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms
Sa'ad, H., et al.
Molecular and Cellular Biology, 1801 (11), 1175-1183 (2010)

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