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W502715

Sigma-Aldrich

Succinic acid

natural

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Synonym(s):
Butanedioic acid
Linear Formula:
HOOCCH2CH2COOH
CAS Number:
110-15-6
Molecular Weight:
118.09
Beilstein/REAXYS Number:
1754069
EC Number:
203-740-4
MDL number:
MFCD00002789
UNSPSC Code:
12164502
PubChem Substance ID:
24902010
Flavis number:
8.024

grade

Kosher
natural

assay

99.0-100.5% (by NaOH, titration)

form

crystalline powder

bp

235 °C (lit.)

mp

184-186 °C (lit.)
185-190 °C

solubility

water: 83 g/L at 25 °C

density

1.564 g/cm3 at 15 °C

cation traces

As: ≤3.0 ppm
Cd: ≤1.0 ppm
Hg: ≤1.0 ppm
Pb: ≤2.0 ppm

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

organoleptic

acidic; sour

SMILES string

OC(=O)CCC(O)=O

InChI

1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)

InChI key

KDYFGRWQOYBRFD-UHFFFAOYSA-N

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pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Succinic acid for synthesis

Sigma-Aldrich

8.22260

Succinic acid

Succinic acid anhydrous, free-flowing, Redi-Dri™, ACS reagent, ≥99.0%

Sigma-Aldrich

797987

Succinic acid

James H Marden et al.
Evolution; international journal of organic evolution, 67(4), 1105-1115 (2013-04-05)
Oxygen conductance to the tissues determines aerobic metabolic performance in most eukaryotes but has cost/benefit tradeoffs. Here we examine in lowland populations of a butterfly a genetic polymorphism affecting oxygen conductance via the hypoxia-inducible factor (HIF) pathway, which senses intracellular
José Manuel Otero et al.
PloS one, 8(1), e54144-e54144 (2013-01-26)
Saccharomyces cerevisiae is the most well characterized eukaryote, the preferred microbial cell factory for the largest industrial biotechnology product (bioethanol), and a robust commerically compatible scaffold to be exploitted for diverse chemical production. Succinic acid is a highly sought after
G M Tannahill et al.
Nature, 496(7444), 238-242 (2013-03-29)
Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch their core metabolism from oxidative phosphorylation to glycolysis. Here we show that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macrophages. A comprehensive metabolic map
Yun Chen et al.
Current opinion in biotechnology, 24(6), 965-972 (2013-04-02)
Bio-based production of chemical building blocks from renewable resources is an attractive alternative to petroleum-based platform chemicals. Metabolic pathway and strain engineering is the key element in constructing robust microbial chemical factories within the constraints of cost effective production. Here
Hilal Taymaz-Nikerel et al.
Metabolic engineering, 16, 115-129 (2013-02-02)
The interactions between the intracellular metabolome, fluxome and growth rate of Escherichia coli after sudden glycolytic/gluconeogenic substrate shifts are studied based on pulses of different substrates to an aerobic glucose-limited steady-state (dilution rate=0.1h(-1)). After each added glycolytic (glucose) and gluconeogenic
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