300205S

Avanti

Pegylated Remote Loadable Liposome (5 mL)

aqueous solution

Synonym(s):
Pegylated Remote Loadable Liposome
NACRES:
NA.25

form

aqueous solution

packaging

pkg of 1 × 5 mL

manufacturer/tradename

Avanti Polar Lipids 300205S

shipped in

dry ice

storage temp.

−20°C

General description

Liposomes are artificial phospholipid vesicles, used to encapsulate and stabilize the drugs and improve their pharmacological properties. PEGylated liposomes are the liposomes modified on the surface with polyethylene glycol (PEG). This PEGylation prevents adsorption of plasma proteins to the liposome surface. This blocks the recognition and uptake of liposomes by the reticoloendothelial system (RES), thereby extending the circulation time of liposomes. PEGylated liposomes (PEGlip) aids in improving the pharmacodynamic properties of therapeutic proteins. PEGlip improves passive targeting ability on tumoral tissues by a process called enhanced permeation retention effect. It enhances the therapeutic effect of the drug and reduces the toxicity of encapsulated drug. The characteristics of PEGlip depends on the PEG linked to the surface, graft density and the distance between graft sites. PEGlyation with greater PEG chains improves the blood residence time.

Packaging

10 mL Clear Glass Vial with Stopper and Crimp Cap (300205S-1EA)

storage_class_code

10 - Combustible liquids

WGK Germany

WGK 2

Certificate of Analysis

Certificate of Origin

PEGylation of proteins and liposomes: a powerful and flexible strategy to improve the drug delivery
Milla P, et al.
Current Drug Metabolism, 13(1), 105-119 (2012)
The use of PEGylated liposomes in the development of drug delivery applications for the treatment of hemophilia
Yatuv R, et al.
International journal of nanomedicine, 5, 581-581 (2010)

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