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330707

Avanti

SPLASH® LIPIDOMIX® Mass Spec Standard

SPLASH® LIPIDOMIX® Mass Spec Standard, methanol solution

NACRES:
NA.25

form

methanol solution

packaging

pkg of 1 × 1 mL (330707-1EA)

manufacturer/tradename

Avanti Polar Lipids 330707

concentration

1 mg/mL (330707-1EA)

shipped in

dry ice

storage temp.

−20°C

General description

Make a splash in your lab and dive right into Lipidomics with our easy to use mixture of deuterium labeled lipids. The SPLASH® LIPIDOMIX® Mass Spec Standard includes all of the major lipid classes at ratios relative to human plasma, allowing one easy internal standard solution to be added to every sample. This internal standard mixture was developed in collaboration with Kim Ekroos (Zora Biosciences).

Application

SPLASH® LIPIDOMIX® Mass Spec Standard has been used:
  • as an internal standard for non-alcoholic fatty liver disease (NAFLD) signature analysis from mice and human samples
  • as an internal standard in the quantification of phospholipids from duodenum, liver, and adipose tissue using ultra performance liquid chromatography quadrupole-time of-flight mass spectrometry (UPLC-q-Tof MS)
  • in human cell lines prior to lipid analysis by liquid chromatography-mass spectrometry (LC-MS) analysis

Features and Benefits

  • Save time: pre-mixed internal standards.
  • Save money: 1 vial is sufficient for 100 plasma samples.
  • Exact concentrations provided for quantitative lipidomic analysis.
  • Applicable to multiple MS approaches.
  • Concentration of each lipid class optimized for plasma analysis.

Packaging

2 mL Amber Glass Sealed Ampule (330707-1EA)

Components

The SPLASH LIPIDOMIX Mass Spec Standard is supplied in 1 mL of methanol and contains the following components:

Mixture ComponentTarget Conc. (μg/mL)
  • 15:0-18:1(d7) PC160
  • 15:0-18:1(d7) PE5
  • 15:0-18:1(d7) PS5
  • 15:0-18:1(d7) PG30
  • 15:0-18:1(d7) PI10
  • 15:0-18:1(d7) PA7
  • 18:1(d7) LPC25
  • 18:1(d7) LPE5
  • 18:1(d7) Chol Ester350
  • 18:1(d7) MG2
  • 15:0-18:1(d7) DG10
  • 15:0-18:1(d7)-15:0 TG55
  • 18:1(d9) SM30
  • Cholesterol (d7)100

Legal Information

LIPIDOMIX is a registered trademark of Avanti Polar Lipids, Inc.
SPLASH is a registered trademark of Avanti Polar Lipids, Inc.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificate of Analysis

Certificate of Origin

Finnur Freyr Eiriksson et al.
PloS one, 15(4), e0231289-e0231289 (2020-04-15)
Breast cancer (BC) is the most prevalent type of cancer in women in western countries. BC mortality has not declined despite early detection by screening, indicating the need for better informed treatment decisions. Therefore, a novel noninvasive diagnostic tool for
Genetic regulation of plasma lipid species and their association with metabolic phenotypes
Jha P, et al.
Cell Systems, 6(6), 709-721 (2018)
Tomoki Naito et al.
eLife, 8 (2019-11-15)
Cholesterol is a major structural component of the plasma membrane (PM). The majority of PM cholesterol forms complexes with other PM lipids, making it inaccessible for intracellular transport. Transition of PM cholesterol between accessible and inaccessible pools maintains cellular homeostasis
M A López-Bascón et al.
Analytical and bioanalytical chemistry, 412(2), 489-498 (2019-11-25)
Polar lipids, especially glycerophospholipids, constitute the main components of cell membranes and are precursors of signaling molecules in many cellular and physiological processes. For this reason, the development of methods with high capability for detection of polar lipids in biological
Valerie Z Wall et al.
Journal of lipid research, 58(6), 1174-1185 (2017-04-19)
Acyl-CoA thioesterase 7 (ACOT7) is an intracellular enzyme that converts acyl-CoAs to FFAs. ACOT7 is induced by lipopolysaccharide (LPS); thus, we investigated downstream effects of LPS-induced induction of ACOT7 and its role in inflammatory settings in myeloid cells. Enzymatic thioesterase

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