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700002P

Avanti

F7-Cholesterol

Avanti Polar Lipids 700002P, powder

Synonym(s):
25,26,26,26,27,27,27-heptafluorocholesterol
Empirical Formula (Hill Notation):
C27H39OF7
CAS Number:
Molecular Weight:
512.59
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (700002P-5mg)

manufacturer/tradename

Avanti Polar Lipids 700002P

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C27H39F7O/c1-16(5-4-12-25(28,26(29,30)31)27(32,33)34)20-8-9-21-19-7-6-17-15-18(35)10-13-23(17,2)22(19)11-14-24(20,21)3/h6,16,18-22,35H,4-5,7-15H2,1-3H3/t16-,18+,19+,20-,21+,22+,23+,24-/m1/s1

InChI key

DUAIJEYNEJQOCE-OLSVQSNTSA-N

General description

F7-Cholesterol is a fluorinated derivative of cholesterol. It is a cholesterol analog. F7-Cholesterol is useful as helper lipid in conjunction with vectors for DNA transfection.

Application

F7-Cholesterol has been used:
  • in the preparation of liposomes for DNA delivery studies
  • to investigate its rescue functionality in hedgehog signaling in sterol-depleted cells
  • in preparation of monolayers for pressure and area isotherms studies

Biochem/physiol Actions

F7-Cholesterol has potential biological applications. It has a negative dipole moment. F7-Cholesterol rescues hedgehog signaling in sterol-depleted cells. The molecular orientation and phospholipid interaction of F7-cholesterol is similar to hydrogenated cholesterol.

Packaging

5 mL Amber Glass Screw Cap Vial (700002P-5mg)

Storage Class Code

13 - Non Combustible Solids

Certificate of Analysis

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Certificate of Origin

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