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700026P

Avanti

3β-hydroxy-7-oxo-5-cholestenoic acid

Avanti Polar Lipids 700026P, powder

Synonym(s):
(25R)-cholest-5-en-26-oic acid, 3β-hydroxy-7-oxo
Empirical Formula (Hill Notation):
C27H42O4
CAS Number:
Molecular Weight:
430.62
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (700026P-5mg)

manufacturer/tradename

Avanti Polar Lipids 700026P

shipped in

dry ice

storage temp.

−20°C

General description

Cholestenoic acids are cholesterol metabolic intermediates and precursors to bile acids. 3β-hydroxy-7-oxo-5-cholestenoic acid is synthesized from 7β-hydroxycholesterol. The enzymes for synthesis of cholestenoic acids are majorly present in the central nervous system (CNS) of mammals. 3β-hydroxy-7-oxo-5-cholestenoic acid (3βH,7O-CA) is also synthesized from 26-hydroxy-7-oxocholesterol by the action of the enzyme cytochrome P450 family 27 subfamily A member 1 sterol 27-hydroxylase (CYP27A1).

Biochem/physiol Actions

3β-hydroxy-7-oxocholest-5-en-26-oic acid (3βH,7O-CA) acts as a ligand for liver X receptors (LXR) and activates them at micromolar concentration. 3βH,7O-CA favors the islet-1+ cells synthesis and islet-1–GFP expression. 3βH,7O-CA also mediates oculomotor neurons maturation and its conversion to 3β,7β-dihydroxycholest-5-en-(25S)26-oic acid (3β,7β-diHCA) is catalyzed by the enzyme hydroxysteroid 11-β dehydrogenase.

Packaging

5 mL Amber Glass Screw Cap Vial (700026P-5mg)

Storage Class Code

13 - Non Combustible Solids

Certificate of Analysis

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Certificate of Origin

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