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7α-hydroxy-3-oxo-4-cholestenoic acid

Avanti Polar Lipids 700027P, powder

(25R)-cholest-4-en-26-oic acid, 7α-hydroxy-3-oxo
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:


>99% (TLC)




pkg of 1 × 1 mg (700027P-1mg)


Avanti Polar Lipids 700027P

shipped in

dry ice

storage temp.


General description

7α-Hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) is synthesized extrahepatically from cholesterol. The enzyme oxysterols-7α-hydrolase (CYP7B1) acts on precursor 27-hydroxycholesterol (27-OHC) to generate 7-HOCA.. 7-HOCA is catabolized in the liver.


7α-hydroxy-3-oxo-4-cholestenoic acid has been used as an analyte in ultra-high-performance liquid chromatography (UHPLC) system.

Biochem/physiol Actions

The levels of 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) in cerebrospinal fluid are not correlated to neurodegeneration but may serve as a diagnostic marker to trace blood-brain barrier integrity.


5 mL Amber Glass Screw Cap Vial (700027P-1mg)

Storage Class Code

13 - Non Combustible Solids

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Quotes and Ordering

Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation
Shafaati M, et al.
Journal of Lipid Research, 52(5), 1004-1010 (2011)
Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome
Madenspacher JH, et al.
The Journal of Allergy and Clinical Immunology, 143(1), 440-442 (2019)
7 ? -hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid reflects the integrity of the blood-brain barrier
Saeed A, et al.
Journal of Lipid Research, 55(2), 313-318 (2014)
Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation
Testa G, et al.
Redox Biology, 10, 24-33 (2016)
Vladimiro Cardenia et al.
Biochimie, 153, 99-108 (2018-08-06)
The electronic cigarettes (e-cigarettes, e-cigs) have become the most sought-after alternative to the traditional cigarettes, partly due to the widespread perception of safety. However, the high temperature reached by e-cig solutions can generate toxic compounds, some of which are listed

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