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700027P

Avanti

7α-hydroxy-3-oxo-4-cholestenoic acid

Avanti Polar Lipids 700027P, powder

Synonym(s):
(25R)-cholest-4-en-26-oic acid, 7α-hydroxy-3-oxo
Empirical Formula (Hill Notation):
C27H42O4
CAS Number:
Molecular Weight:
430.62
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700027P-1mg)

manufacturer/tradename

Avanti Polar Lipids 700027P

shipped in

dry ice

storage temp.

−20°C

General description

7α-Hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) is synthesized extrahepatically from cholesterol. The enzyme oxysterols-7α-hydrolase (CYP7B1) acts on precursor 27-hydroxycholesterol (27-OHC) to generate 7-HOCA.. 7-HOCA is catabolized in the liver.

Application

7α-hydroxy-3-oxo-4-cholestenoic acid has been used as an analyte in ultra-high-performance liquid chromatography (UHPLC) system.

Biochem/physiol Actions

The levels of 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) in cerebrospinal fluid are not correlated to neurodegeneration but may serve as a diagnostic marker to trace blood-brain barrier integrity.

Packaging

5 mL Amber Glass Screw Cap Vial (700027P-1mg)

Storage Class Code

13 - Non Combustible Solids

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

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