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700029P

Avanti

3β,7β-dihydroxy-5-cholestenoic acid

Avanti Polar Lipids 700029P, powder

Synonym(s):
(25R)-cholest-5-en-26-oic acid, 3β,7β-hydroxy
Empirical Formula (Hill Notation):
C27H44O4
CAS Number:
Molecular Weight:
432.64
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700029P-1mg)

manufacturer/tradename

Avanti Polar Lipids 700029P

shipped in

dry ice

storage temp.

−20°C

General description

3β,7β-dihydroxy-5-cholestenoic acid (3β,7β-diHCA) is associated with plasma and is a C27 acid. 3β,7β-diHCA is synthesized from 3β-hydroxy-7-oxocholest-5-en-(25R)26-oic acid (3βH,7O-CA) by the action of the enzyme hydroxysteroid 11-β dehydrogenase 1.

Application

3β,7β-dihydroxy-5-cholestenoic acid may be used as an authentic diastereoisomer standard in mass spectrometry (MS) experiments.

Biochem/physiol Actions

3β,7β-dihydroxy-5-cholestenoic acid (3β,7β-diHCA) levels are elevated in Niemann-Pick type C (NPC) disease and Niemann-Pick (NP) disease type B disorders. It elicits toxicity to oculomotor neurons.

Packaging

5 mL Amber Glass Screw Cap Vial (700029P-1mg)

Storage Class Code

13 - Non Combustible Solids

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More documents

Quotes and Ordering

Charge-tagging liquid chromatography-mass spectrometry methodology targeting oxysterol diastereoisomers
Griffiths WJ, et al.
Chemistry and Physics of Lipids, 207, 69-80 (2017)
Sterolomics in biology, biochemistry, medicine
Griffiths WJ and Wang Y
TrAC, Trends in Analytical Chemistry, 115280-115280 (2018)
Metabolism of non-enzymatically derived oxysterols: clues from sterol metabolic disorders
Griffiths WJ, et al.
Free Radical Biology & Medicine, 144, 124-133 (2019)

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