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700036P

Avanti

4β-hydroxycholesterol

cholest-5-ene-3β,4β-diol, powder

All Photos(2)
Synonym(s):
cholest-5-ene-3b,4b-diol; 110803
Empirical Formula (Hill Notation):
C27H46O2
CAS Number:
17320-10-4
Molecular Weight:
402.65
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (700036P-10mg)
pkg of 1 × 5 mg (700036P-5mg)

manufacturer/tradename

Avanti Polar Lipids 700036P

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C27H46O2/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23-25(29)24(28)14-16-27(23,5)22(19)13-15-26(20,21)4/h10,17-22,24-25,28-29H,6-9,11-16H2,1-5H3

InChI key

CZDKQKOAHAICSF-UHFFFAOYSA-N

General description

4β-hydroxycholesterol is an endogenous oxysterol, which is formed by cytochrome P450 3A (CYP3A4) and CYP3A5.

Biochem/physiol Actions

4β-hydroxycholesterol acts as a marker for cytochrome P450 3A (CYP3A4/5) activity.

Packaging

5 mL Amber Glass Screw Cap Vial (700036P-10mg)
5 mL Amber Glass Screw Cap Vial (700036P-5mg)

Storage Class Code

13 - Non Combustible Solids

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

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More Documents

Structure Search

Quotes and Ordering

Bulk Quote-Order Product
4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin
Diczfalusy U, et al.
British Journal of Clinical Pharmacology, 67(1), 38-43 (2009)
Michael E Abrams et al.
Nature microbiology, 5(7), 929-942 (2020-04-15)
Cholesterol 25-hydroxylase (CH25H) is an interferon-stimulated gene that converts cholesterol to the oxysterol 25-hydroxycholesterol (25HC). Circulating 25HC modulates essential immunological processes including antiviral immunity, inflammasome activation and antibody class switching; and dysregulation of CH25H may contribute to chronic inflammatory disease

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