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700040P

Avanti

desmosterol-d6

cholesta-5,24-dien-3β-ol-d6, powder

Synonym(s):
24-dehydrocholesterol(d6); 5,24-cholestadien-3β-ol(d6)
Empirical Formula (Hill Notation):
C27H38OD6
CAS Number:
Molecular Weight:
390.67
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700040P-1mg)

manufacturer/tradename

Avanti Polar Lipids 700040P

shipped in

dry ice

storage temp.

−20°C

General description

Desmosterol constitutes 1% of brain sterol and is catabolized to cholesterol by the enzyme 3-hydroxysterol 24-reductase (DHCR24). It is an intermediate in the Bloch branch of the cholesterol biosynthesis pathway. Desmosterol-d6 is a deuterated form of desmosterol.

Application

Desmosterol-d6 has been used:
  • as a deuterated standard in liquid chromatography multiple reaction monitoring (LC-MRM)
  • as a deuterated standard in high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS)
  • for spiking brain tissue homogenate from Alzheimer′s disease (AD) for liquid chromatography -mass spectrometry (LC-MS) analysis

Biochem/physiol Actions

Desmosterol low levels in the hippocampus directly impacts progenitor cell differentiation into neurons. Desmosterol-d6 is used as a substitute to desmosterol in hepatitis C virus (HCV) based viral assays to rescue replication. Desmosterol being a C27 sterol intermediate is implicated in the Alzheimer′s disease (AD) pathogenesis.

Packaging

5 mL Amber Glass Screw Cap Vial (700040P-1mg)

Storage Class Code

13 - Non Combustible Solids

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Quotes and Ordering

Valerie A Villareal et al.
ACS chemical biology, 11(7), 1827-1833 (2016-04-30)
Hepatitis C virus (HCV) increases intracellular desmosterol without affecting the steady-state abundance of other sterols, and the antiviral activity of inhibitors of desmosterol synthesis is suppressed by the addition of exogenous desmosterol. These observations suggest a model in which desmosterol
Yoshiaki Sato et al.
Alzheimer's & dementia (Amsterdam, Netherlands), 1(1), 67-74 (2015-03-01)
We here examined whether plasma desmosterol-to-cholesterol ratio (DES/CHO) is decreased in patients with Alzheimer's disease (AD) and investigated the association between plasma DES/CHO and longitudinal cognitive decline. Plasma DES/CHO of AD patients and age-matched controls in a Japanese cross-sectional cohort
Jeffrey G McDonald et al.
Methods in enzymology, 432, 145-170 (2007-10-24)
We describe the development of a high performance liquid chromatography mass spectrometry (HPLC-MS) method that allows the identification and quantitation of sterols in mammalian cells and tissues. Bulk lipids are extracted from biological samples by a modified Bligh/Dyer procedure in
Priyadarshini Chakrabarti et al.
Metabolomics : Official journal of the Metabolomic Society, 15(10), 127-127 (2019-09-21)
Significant annual honey bee colony losses have been reported in the USA and across the world over the past years. Malnutrition is one among several causative factors for such declines. Optimal nutrition serves as the first line of defense against
Thomas Wisniewski et al.
Journal of Alzheimer's disease : JAD, 33(3), 881-888 (2012-10-09)
Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It has become of particular interest in the pathogenesis of Alzheimer's disease (AD) because of the report that the activity of

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