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700071P

Avanti

24(R)-hydroxycholesterol

cholest-5-ene-3β,24(R)-diol, powder

Synonym(s):
5-cholestene-3β,24-diol  ; 24-hydroxycholest-5-en-3-ol
Empirical Formula (Hill Notation):
C27H46O2
CAS Number:
Molecular Weight:
402.65
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700071P-1mg)

manufacturer/tradename

Avanti Polar Lipids 700071P

shipped in

dry ice

storage temp.

−20°C

General description

24-hydroxycholesterol (24-OH) is an oxidized product of cholesterol. It is synthesized in the presence of enzyme 24S-hydroxylase (CYP46A1).

Biochem/physiol Actions

24(S)-hydroxycholesterol is preferred over 24(R)-hydroxycholesterol by human 7α-hydroxylase. However, the porcine enzyme is active towards both isomers. 24-hydroxycholesterol (24-OH) favors sirtuin 1 expression and reduces the tau protein phosphorylation.

Packaging

5 mL Amber Glass Screw Cap Vial (700071P-1mg)

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Quotes and Ordering

Gabriella Testa et al.
Redox biology, 17, 423-431 (2018-06-09)
It is now established that cholesterol oxidation products (oxysterols) are involved in several events underlying Alzheimer's disease (AD) pathogenesis. Of note, certain oxysterols cause neuron dysfunction and degeneration but, recently, some of them have been shown also to have neuroprotective
M Norlin et al.
Journal of lipid research, 41(10), 1629-1639 (2000-10-03)
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this oxysterol. In the

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