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700077P

Avanti

FF-MAS

14-demethyl-14-dehydrolanosterol, powder

Synonym(s):
4,4-dimethyl-5α-cholesta-8,14,24-trien-3β-ol; follicular fluid meiosis-activating sterol
Empirical Formula (Hill Notation):
C29H46O
CAS Number:
Molecular Weight:
410.67
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700077P-1mg)

manufacturer/tradename

Avanti Polar Lipids 700077P

shipped in

dry ice

storage temp.

−70°C

InChI

1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1

InChI key

LFQXEZVYNCBVDO-PBJLWWPKSA-N

General description

Follicular fluid meiosis-activating sterol (FF-MAS) is an intermediate in the cholesterol biosynthetic pathway present in all cells, and may represent the physiological signal that instructs the oocyte to reinitiate meiosis.

Application

FF-MAS has been used:
  • as a standard in gas chromatography/ mass spectroscopy (GC/MS) for profiling sterols of oligodendrocyte progenitor cells (OPCs)
  • as Dulbecco′s modified eagle medium (DMEM) medium supplement to test its effect on cancer cell viability
  • to evaluate its effect on LXRβ-overexpressing squamous carcinoma SCC61 cells

Biochem/physiol Actions

14-demethyl-14-dehydrolanosterol (FF-MAS) was first identified in follicular fluid of women and plays a key role in oocyte nuclear maturation. The levels of FF-MAS may be regulated by cytochrome P450 family 27 subfamily A member 1. Supplementation of FF-MAS to oocytes promotes meiotic maturation favoring preimplantation. However, FF-MAS has low solubility and is metabolized to cholesterol rapidly.

Packaging

5 mL Amber Glass Screw Cap Vial (700077P-1mg)

Storage Class Code

13 - Non Combustible Solids

Certificate of Analysis

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Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

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