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700083P

Avanti

3-oxo-4-cholestenoic acid

(25R)-cholest-4-en-26-oic acid, 3-oxo, powder

Synonym(s):
cholest-4-en-3-one-27-oic acid
Empirical Formula (Hill Notation):
C27H42O3
CAS Number:
Molecular Weight:
414.62
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700083P-1mg)

manufacturer/tradename

Avanti Polar Lipids 700083P

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC1(CC2)C(CCC3C1CCC4(C)C3CCC4C(CCCC(C)C(O)=O)C)=CC2=O

General description

3-oxo-4-cholestenoic acid (3OChA) is synthesized from cholesterol by the oxidation at the positions C3 and C26 in the presence of P450 cytochromes (CYP125 and CYP142). This pathway is well established in M. smegmatis. 3OChA is an intermediate in cholesterol catabolism and is more soluble compared to cholesterol.

Application

3-oxo-4-cholestenoic acid has been used as a inducer ligand for the TetR-like repressor (KstR) of M. smegmatis.

Biochem/physiol Actions

3-oxo-4-cholestenoic acid (3OChA) acts as an inducer to the TetR-like repressor (KstR) and modulates the expression kstR regulon genes.

Packaging

5 mL Amber Glass Screw Cap Vial (700083P-1mg)

Storage Class Code

13 - Non Combustible Solids

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More documents

Quotes and Ordering

Esther García-Fernández et al.
The Journal of biological chemistry, 289(25), 17576-17588 (2014-05-08)
Cholesterol degradation plays a prominent role in Mycobacterium tuberculosis infection; therefore, to develop new tools to combat this disease, we need to decipher the components comprising and regulating the corresponding pathway. A TetR-like repressor (KstR) regulates the upper part of

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