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700125P

Avanti

DMHCA

Avanti Polar Lipids 700125P, powder

Synonym(s):
N,N-dimethyl-3β-hydroxycholenamide
Empirical Formula (Hill Notation):
C26H43NO2
CAS Number:
Molecular Weight:
401.63
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (700125P-5mg)

manufacturer/tradename

Avanti Polar Lipids 700125P

shipped in

dry ice

storage temp.

−20°C

General description

N,N-dimethyl-3β-hydroxy-cholenamide (DMHCA) is a potent steroidal liver X receptor (LXR) ligand in vitro and in vivo. It is used to treat atherosclerosis.
N,N-dimethyl-3β-hydroxycholenamide (DHMCA) is a synthetic ligand for liver X receptor (LXR).

Application

DMHCA has been used as LXR activator to treat retinal endothelial cells in order to activate the sirtuin 1- liver X receptors (SIRT1-LXR) pathway.
It may be used as 3β-hydroxysterol-Δ24-reductase (DHCR24) inhibitor.

Biochem/physiol Actions

N,N-dimethyl-3β-hydroxycholenamide (DHMCA) halts cholesterol biosynthesis by inhibiting 3β-hydroxysterol-Δ24-reductase (DHCR24) enzyme. It may serve as a therapeutic agent for treating atherosclerosis, age-related macular degeneration and diabetic retinopathy.
DMHCA (N,N-dimethyl-3β-hydroxycholenamide) is a synthetic oxysterol and is an agonist for liver X receptors (LXR). It promotes cholesterol transport, expression of adenosine triphosphate (ATP) binding cassette transporters. DMHCA suppresses the proinflammatory cytokines stimulation, induced by oxysterol.

Packaging

5 mL Amber Glass Screw Cap Vial (700125P-5mg)

Storage Class Code

13 - Non Combustible Solids

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

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Synthetic LXR agonist attenuates plaque formation in apoE-/-mice without inducing liver steatosis and hypertriglyceridemia
Kratzer A, et al.
Journal of Lipid Research, 50(2), 312-326 (2009)
Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor.
Quinet E M, et al.
Journal of Lipid Research, 45(10), 1929-1942 (2004)
The mechanism of diabetic retinopathy pathogenesis unifying key lipid regulators, sirtuin 1 and liver X receptor
Hammer SS, et al.
EBioMedicine, 22, 181-190 (2017)
Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein
Scoles DR, et al.
Gynecologic Oncology, 116(1), 109-116 (2010)
Thomas Pfeifer et al.
Current pharmaceutical biotechnology, 12(2), 285-292 (2010-12-31)
The liver X receptors (LXRs) are key regulators of genes involved in cholesterol homeostasis. Natural ligands and activators of LXRs are oxysterols. Numerous steroidal and non-steroidal synthetic LXR ligands are under development as potential drugs for individuals suffering from lipid

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