Cholestenoic acid-d5 is an endogenous cholesterol metabolite. It is produced in extrahepatic organs.
Cholestenoic acid levels in plasma ranges between 100-300 nM and is synthesized in brain. Cholestenoic acid is generated by the side chain oxidation of 27-hydroxy-cholesterol and is an intermediate in the bile synthesis pathway.
Cholestenoic acid-d5 functions as a potent steroid γ-secretase modulator (GSM).
Cholestenoic acid is a carboxylic acid γ-secretase modulator. Cholestenoic acid also serves as a ligand for liver X receptor. Cholestenoic acid -d5 regulates amyloid β peptides (Aβ) levels. It reduces Aβ42 levels and enhances Aβ38 levels. In retina, it is the major byproduct of cholesterol elimination. 27-hydroxycholesterol and cholestenoic acid are part of reverse cholesterol transport in macrophages and their transport impairment is implicated in premature atherosclerosis.
5 mL Amber Glass Screw Cap Vial (700151P-1mg)
Storage Class Code
13 - Non Combustible Solids
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Cholestenoic acid, an endogenous cholesterol metabolite, is a potent gamma-secretase modulator
Jung JI, et al.
Mol. Neurodegener., 10(1), 29-29 (2015)
Cholestenoic acid is a naturally occurring ligand for liver X receptor alpha
Song C and Liao S
Endocrinology, 141(11), 4180-4184 (2000)
Cholestenoic acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain
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