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700151P

Avanti

cholestenoic acid-d5

Avanti Polar Lipids 700151P, powder

Synonym(s):
3β-hydroxy-5-cholestenoic acid-d5
Empirical Formula (Hill Notation):
C27H39 D5O3
CAS Number:
Molecular Weight:
421.67
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700151P-1mg)

manufacturer/tradename

Avanti Polar Lipids 700151P

shipped in

dry ice

storage temp.

−20°C

General description

Cholestenoic acid-d5 is an endogenous cholesterol metabolite. It is produced in extrahepatic organs.
Cholestenoic acid levels in plasma ranges between 100-300 nM and is synthesized in brain. Cholestenoic acid is generated by the side chain oxidation of 27-hydroxy-cholesterol and is an intermediate in the bile synthesis pathway.

Biochem/physiol Actions

Cholestenoic acid-d5 functions as a potent steroid γ-secretase modulator (GSM).
Cholestenoic acid is a carboxylic acid γ-secretase modulator. Cholestenoic acid also serves as a ligand for liver X receptor. Cholestenoic acid -d5 regulates amyloid β peptides (Aβ) levels. It reduces Aβ42 levels and enhances Aβ38 levels. In retina, it is the major byproduct of cholesterol elimination. 27-hydroxycholesterol and cholestenoic acid are part of reverse cholesterol transport in macrophages and their transport impairment is implicated in premature atherosclerosis.

Packaging

5 mL Amber Glass Screw Cap Vial (700151P-1mg)

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Certificate of Analysis

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Certificate of Origin

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