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700156P

Avanti

20α-hydroxycholesterol

Avanti Polar Lipids 700156P, powder

Synonym(s):
5-cholestene-3α,20α-diol
Empirical Formula (Hill Notation):
C27H46 O2
CAS Number:
Molecular Weight:
402.65
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (700156P-10mg)
pkg of 1 × 5 mg (700156P-5mg)

manufacturer/tradename

Avanti Polar Lipids 700156P

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1

InChI key

MCKLJFJEQRYRQT-APGJSSKUSA-N

Application

20α-hydroxycholesterol or 5-cholestene-3α,20α-diol has been used to study the role of oxysterols on mammalian immune function.

Packaging

5 mL Amber Glass Screw Cap Vial (700156P-10mg)
5 mL Amber Glass Screw Cap Vial (700156P-5mg)

Hazard Statements

Hazard Classifications

Aquatic Chronic 4

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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Michael E Abrams et al.
Nature microbiology, 5(7), 929-942 (2020-04-15)
Cholesterol 25-hydroxylase (CH25H) is an interferon-stimulated gene that converts cholesterol to the oxysterol 25-hydroxycholesterol (25HC). Circulating 25HC modulates essential immunological processes including antiviral immunity, inflammasome activation and antibody class switching; and dysregulation of CH25H may contribute to chronic inflammatory disease

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