MilliporeSigma
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810251P

Avanti

NBD-6 Cholesterol

Avanti Polar Lipids 810251P, powder

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Synonym(s):
5-cholesten-3β-ol 6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]caproate
Empirical Formula (Hill Notation):
C39H58N4O5
CAS Number:
201731-19-3
Molecular Weight:
662.90
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (810251P-1mg)

manufacturer/tradename

Avanti Polar Lipids 810251P

shipped in

dry ice

storage temp.

−20°C

General description

NBD-6 Cholesterol is a fluorescent analog of the lipoprotein compound cholesterol, with NBD (2-(4-nitro-2,1,3-benzoxadiazol-7-yl) aminoethyl) being the fluorescent group.

Application

NBD-6 Cholesterol has been used for NBD-cholesterol binding assay, to study the binding of fluorescent NBD cholesterol in the binding pocket concerning ASTER domains.

Biochem/physiol Actions

Cholesterol is produced from acetyl-CoA by a complex multistep mevalonate pathway. In mammals, liver is the main site of de novo cholesterol synthesis contributing to almost 80% of total cholesterol synthesis. Cholesterol and its metabolites, along with its precursors, play important roles in cellular membrane physiology. They also have roles in reproductive biology, dietary nutrient absorption, stress responses, salt and water balance and calcium metabolism.

Packaging

5 mL Amber Glass Screw Cap Vial (810251P-1mg)

Storage Class Code

13 - Non Combustible Solids

Certificate of Analysis

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Certificate of Origin

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Molecular Nutrition And Food Research, 277-290 (2016)
Fluorescent and Luminescent Probes for Biological Activity (1999)
Cholesterol in health and disease.
Ira Tabas
The Journal of clinical investigation, 110(5), 583-590 (2002-09-05)
Pedro M R Cruz et al.
Frontiers in pharmacology, 4, 119-119 (2013-10-05)
While the unique metabolic activities of malignant tissues as potential targets for cancer therapeutics has been the subject of several recent reviews, the role of cholesterol metabolism in this context is yet to be fully explored. Cholesterol is an essential
Jaspreet Sandhu et al.
Cell, 175(2), 514-529 (2018-09-18)
The mechanisms underlying sterol transport in mammalian cells are poorly understood. In particular, how cholesterol internalized from HDL is made available to the cell for storage or modification is unknown. Here, we describe three ER-resident proteins (Aster-A, -B, -C) that

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