All Photos(1)

810335C

Avanti

18:1 Cy5 PE

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(Cyanine 5), chloroform

Empirical Formula (Hill Notation):
C73H118ClN4O9P
CAS Number:
Molecular Weight:
1262.17
NACRES:
NA.25

assay

>99% (TLC)

packaging

pkg of 1 × 1 mL (810335C-1mg)
pkg of 5 × 1 mL (810335C-5mg)

concentration

1 mg/mL (810335C-1mg)
1 mg/mL (810335C-5mg)

shipped in

dry ice

storage temp.

−20°C

Application

18:1 Cy5 PE or 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(Cyanine 5), chloroform has been used:
  • as a standard for the estimation of absolute density of Cy5 labeled Trx-His6-NCav-CT on supported lipid bilayers (SLB)
  • in annexin-coated vesicle production
  • to label vesicle types in order to optically distinguish them from other vesicles and to initiate biochemical reactions in a cell-mimetic compartment

Biochem/physiol Actions

Fluorescent labelled lipids are generally useful in cell biology and biophysical studies. Cellular events involving lipids such as lipid domain generation, disaggregation and re-organization can be studied with fluorescent lipids. They are also useful in analyzing the physical properties of lipid bilayers.

Packaging

5 mL Amber Glass Screw Cap Vial (810335C-5mg)
5 mL Amber Glass Screw Cap Vial (810335C-1mg)

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Certificate of Analysis

Certificate of Origin

Xiandeng Wu et al.
Molecular cell, 73(5), 971-984 (2019-01-22)
Both the timing and kinetics of neurotransmitter release depend on the positioning of clustered Ca2+ channels in active zones to docked synaptic vesicles on presynaptic plasma membranes. However, how active zones form is not known. Here, we show that RIM...
Guido Bolognesi et al.
Nature communications, 9(1), 1882-1882 (2018-05-16)
Constructing higher-order vesicle assemblies has discipline-spanning potential from responsive soft-matter materials to artificial cell networks in synthetic biology. This potential is ultimately derived from the ability to compartmentalise and order chemical species in space. To unlock such applications, spatial organisation...
Kevin Bode et al.
Cell reports, 29(13), 4435-4446 (2019-12-26)
Uptake of apoptotic cells (ACs) by dendritic cells (DCs) and induction of a tolerogenic DC phenotype is an important mechanism for establishing peripheral tolerance to self-antigens. The receptors involved and underlying signaling pathways are not fully understood. Here, we identify Dectin-1 as a...
Margrethe A Boyd et al.
Biophysical journal, 115(7), 1307-1315 (2018-09-17)
Cells dynamically regulate their membrane surface area during a variety of processes critical to their survival. Recent studies with model membranes have pointed to a general mechanism for surface area regulation under tension in which cell membranes unfold or take...
Ulrike Bruning et al.
Cell metabolism, 28(6), 866-880 (2018-08-28)
The role of fatty acid synthesis in endothelial cells (ECs) remains incompletely characterized. We report that fatty acid synthase knockdown (FASNKD) in ECs impedes vessel sprouting by reducing proliferation. Endothelial loss of FASN impaired angiogenesis in vivo, while FASN blockade reduced...

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