840022C

Avanti

Brain PE

L-α-phosphatidylethanolamine (Brain, Porcine), chloroform

CAS Number:
NACRES:
NA.25

assay

>99% (TLC)

packaging

pkg of 1 × 2.5 mL (840022C-25mg)
pkg of 2 × 4 mL (840022C-200mg)

manufacturer/tradename

Avanti Polar Lipids 840022C

concentration

10 mg/mL (840022C-25mg)
25 mg/mL (840022C-200mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O

General description

Contains ~50% plasmalogen ether lipid

Application

Brain PE has been used as a cofactor to support the replication of highly infectious prion protein (PrPSc). It has also been used for the preparation of liposomes.

Packaging

5 mL Clear Glass Sealed Ampule (840022C-200mg)
5 mL Clear Glass Sealed Ampule (840022C-25mg)

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Target Organs

Central nervous system

RIDADR

UN 1888 6.1 / PGIII

WGK Germany

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Certificate of Analysis

Certificate of Origin

Preserving prion strain identity upon replication of prions in vitro using recombinant prion protein
Makarava N, et al.
Acta Neuropathologica Communications, 6(1), 92-92 (2018)
Contrasting effects of two lipid cofactors of prion replication on the conformation of the prion protein
Srivastava S and Baskakov IV
Testing, 10(6), e0130283-e0130283 (2015)
Saurabh Srivastava et al.
PloS one, 10(6), e0130283-e0130283 (2015-06-20)
Recent studies introduced two experimental protocols for converting full-length recombinant prion protein (rPrP) purified from E.coli into the infectious prion state (PrPSc) with high infectivity titers. Both protocols employed protein misfolding cyclic amplification (PMCA) for generating PrPSc de novo, but...
Arupratan Das et al.
Nature cell biology, 14(3), 304-310 (2012-02-22)
Lipid asymmetry at the plasma membrane is essential for such processes as cell polarity, cytokinesis and phagocytosis. Here we find that a lipid flippase complex, composed of Lem3, Dnf1 or Dnf2, has a role in the dynamic recycling of the...
Ksenia Rostislavleva et al.
Science (New York, N.Y.), 350(6257), aac7365-aac7365 (2015-10-10)
Phosphatidylinositol 3-kinase Vps34 complexes regulate intracellular membrane trafficking in endocytic sorting, cytokinesis, and autophagy. We present the 4.4 angstrom crystal structure of the 385-kilodalton endosomal complex II (PIK3C3-CII), consisting of Vps34, Vps15 (p150), Vps30/Atg6 (Beclin 1), and Vps38 (UVRAG). The...

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