840026C

Avanti

Liver PE

L-α-phosphatidylethanolamine (Liver, Bovine), chloroform

CAS Number:
NACRES:
NA.25

assay

>99% (TLC)

packaging

pkg of 1 × 2.5 mL (840026C-25mg)
pkg of 5 × 4 mL (840026C-500mg)

manufacturer/tradename

Avanti Polar Lipids 840026C

concentration

10 mg/mL (840026C-25mg)
25 mg/mL (840026C-500mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O

General description

Phosphatidylethanolamine (PE) consists of a small polar head group with fatty acid chains. It is the second most plenteous glycerophospholipid in eukaryotic cells. PE is a non-bilayer forming phospholipid. It is found abundantly in the mitochondria.

Application

Liver PE is suitable for the preparation of liposomes.

Biochem/physiol Actions

Phosphatidylethanolamine (PE) is involved in providing rigidity to the cell membrane via hexagonal phase structures, which promote tight packing of the membrane bilayer formed by phosphotidylcholine. It is also involved in the conversion of prions from the non-toxic to toxic conformation. PE also initiates the autophagosome formation by attaching covalently to the autophagy Atg8 protein.

Packaging

5 mL Clear Glass Sealed Ampule (840026C-500mg)
5 mL Clear Glass Sealed Ampule (840026C-25mg)

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Target Organs

Central nervous system

RIDADR

UN 1888 6.1 / PGIII

WGK Germany

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Certificate of Analysis

Certificate of Origin

Phosphatidylethanolamine metabolism in health and disease
International Review of Cell and Molecular Biology, 321, 29-88 (2016)
Ethanolamine and Phosphatidylethanolamine Partners in Health and Disease
Patel D and Witt SN
Oxidative Medicine and Cellular Longevity, 2017, 29-88 (2017)
A novel flow cytometric assay to quantify interactions between proteins and membrane lipids
Temmerman K and Nickel W
Journal of Lipid Research, 50(6), 1245-1254 (2009)
Nadezhda Y Davydova et al.
The Biochemical journal, 476(23), 3661-3685 (2019-11-22)
In this study, we investigate the ability of ethanol-inducible CYP2E1 to interact with other cytochrome P450 species and affect the metabolism of their substrates. As a model system, we used CYP2E1-enriched human liver microsomes (HLM) obtained by the incorporation of...
Koen Temmerman et al.
Journal of lipid research, 50(6), 1245-1254 (2009-01-16)
A diverse set of experimental systems has been developed to probe protein-lipid interactions. These include measurements with the headgroups of membrane lipids in solution, immobilized membrane lipids, and analysis of protein binding to membrane lipids reconstituted in liposomes. Each of...

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