840035C

18:1 PS (DOPS)

1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodium salt), chloroform

• Synonym(s): 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine (sodium salt); DOPS; PS(18:1(9Z)/18:1(9Z))
• Empirical Formula (Hill Notation): C₄₂H₇₇NO₁₀PNa
• CAS Number: 90693-88-2
• Molecular Weight: 810.03
• NACRES: NA.25

Properties

• assay: >99% (TLC)
• form: liquid
• packaging: pkg of 1 × 1 mL (840035C-10mg); pkg of 1 × 2.5 mL (840035C-25mg); pkg of 2 × 4 mL (840035C-200mg); pkg of 5 × 4 mL (840035C-500mg)
• manufacturer/tradename: Avanti Polar Lipids 840035C
• concentration: 10 mg/mL (840035C-10mg); 10 mg/mL (840035C-25mg); 25 mg/mL (840035C-200mg); 25 mg/mL (840035C-500mg)
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]
• InChI: 1S/C42H78NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h17-20,38-39H,3-16,21-37,43H2,1-2H3,(H,46,47)(H,48,49);/q;+1/p-1/b19-17-,20-18-;/t38-,39+;/m1./s1
• InChI key: KPHZNDUWYZIXFY-YORIBCANSA-M

Description

General description

DOPS is an excellent substitute for the naturally occurring Brain PS. It has similar physical properties and is more stable to oxidation. DOPS has been used, along with DOPC and DOPE, in lipid mixtures to mimic platelet membranes for coagulation studies.

Phosphoserine/phosphatidylserine (PS) is an endogenous phospholipid, that is found in all polyanionic macromolecules. 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) carry a carboxylic acid group and a protonated amine group in their head group.

Application

18:1 PS (DOPS) has been used as a component of supported membrane tubes (SMrT) templates. It has also been used in the preparation of lipid-mixing vesicles, content-mixing vesicles and lipid mixture.

Packaging

10, 25, 200, 500 mg

1 g

30 mL Amber Narrow Mouth Bottle with Screw Cap (840035C-500mg)

5 mL Clear Glass Sealed Ampule (840035C-10mg)

5 mL Clear Glass Sealed Ampule (840035C-200mg)

5 mL Clear Glass Sealed Ampule (840035C-25mg)

Biochem/physiol Actions

Phosphoserine (PS) can be used as a template for the recognition of cancer antigen 125 (CA 125). It is very essential for healthy nerve cell membranes and myelin. Exogenous PS can be actively absorbed in humans. It plays a key role in the formation of short-term memory, the consolidation of long-term memory, the ability to create new memories and several other cognitive activities. It actively participates in the locomotor functions, like rapid reactions and reflexes.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H302 - H315 - H319 - H331 - H336 - H351 - H361d - H372 - H412
• Precautionary Statements: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Target Organs: Central nervous system
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable